李新立--心力衰竭治疗的新策略.pptx(芪苈基础与临床证据2015、5、30络病会).pptVIP

ACEI/ARB β Blockers MRAs，盐皮质激素受体拮抗剂 On a background of standard treatment, Qili Qiangxin capsules further reduced the levels of NT-proBNP. Together, our data suggest that Qili Qiangxin capsules could be used in combination therapy for CHF. The Percent Change in the MLHFQ Scores from Baseline through 12 Weeks of Follow-up Composite cardiac events Adverse Events Conclusion Cover Letter:To our knowledge, this is the first randomized controlled trial of chronic heart failure (CHF) treated by traditional Chinese medicine in China or elsewhere Tang WH, Huang Y. Cardiotonic Modulation in Heart Failure: Insights from Traditional Chinese Medicine. J Am Coll Cardiol. 2013;62(12):1073-1074. Editorial Comment— Cardiotonic Modulation in Heart Failure: Insights from Traditional Chinese Medicine— 让衰竭的心脏更加强劲-中国传统医学给我们的启示 基础研究证据 Part I: Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice Tao L, Shen S, Fu S, et al. Sci Rep 2015;5:8374 (IF:5.578) QLQX improves cardiac function and preserves cardiomyocyte architecture QLQX decreases cardiac fibrosis QLQX attenuates cardiac apoptosis QLQX improves cardiac function and survival rate AMI via increasing PPARγ QLQX attenuates cardiac fibrosis and apoptosis via PPARγ QLQX provides beneficial effects in remodeling phase 临床意义 作为预防心肌梗死后心室重构导致心衰的治疗策略之一？（B阶段）（RAS/BB/Ald） Part II: Qiliqiangxin protects against cardiac ischemia-reperfusion injury via mTOR pathway Zhou YL, Fang H, Lin SH, et al. Cell Physiol Biochem 2015 in revision (IF:3.55) A. PCR B. C. Ang II CTL Part III: Qiliqiangxin attenuates cardiac hypertrophy by targeting miR-21(撰写中近期投稿 Unpublished Data) Figure 1 CTL Ang II CTL+QL Ang II+QL D. E. F. Figure 2 A. B. C. Figure 3 B. A. PCR NRCM n=6 细胞免疫荧光 CTL 21 mimic+Ang II+QL Ang II Ang II+QL NC mimic+Ang II+QL C. A B C D Part IV: The treatment effects of Qiliqiangxin on Doxorubicin induced myocardiosis Figure 1 A B C D Figure 2 Slide 26 Pro