Comparative study of intrathecal hyperbaric Bupivacaine with Clonidine, Fentanyl and Midazolam for quality of anaesthesia and duration of post opera- tive pain relief in patients undergoing elective caesarean section.docVIP

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Comparative study of intrathecal hyperbaric Bupivacaine with Clonidine, Fentanyl and Midazolam for quality of anaesthesia and duration of post opera- tive pain relief in patients undergoing elective caesarean section.doc

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Comparative study of intrathecal hyperbaric Bupivacaine with Clonidine, Fentanyl and Midazolam for quality of anaesthesia and duration of post opera- tive pain relief in patients undergoing elective caesarean section

Research Article Comparative study of intrathecal hyperbaric Bupivacaine with Clonidine, Fentanyl and Midazolam for quality of anaesthesia and duration of post opera- tive pain relief in patients undergoing elective caesarean section Anjali Bhure, Neelakshi Kalita, Prasad Ingley, C.P. Gadkari Department of Anaesthesiology, NKP Salve Institute of Medical Sciences Lata Mangeshkar Hospital, Nagpur (Received June, 2011) (Accepted October, 2011) Abstract: Pain free postoperative period and early ambulation are the need of the day for mothers caring for their neonates.The use of adjuvants in spinal analgesia has gained popularity in recent times. This prospective randomized study was carried out among 120 patients scheduled for elective caesarian section. They were divided into 4 groups. GroupA(Control) received Injection Bupivacaine (Hyperbaric) along with 0.9% Normal saline, Group B, C and D received Clonidine 75 μg, Fentanyl 25 μg and Midazolam 2.5 mg along with injection Bupivacaine (H) respectively. The results of the present study showed that intrathecal Clonidine, Fentanyl and Midazolam can be used safely in parturient, provided strict protocol for preloading is followed by vigilant operative and post-operative monitoring by a trained person. Requirement of postoperative analgesics was found to be significantly reduced in all the study groups when compared with the control group. The highest duration of pain relief was found with Clonidine. Adverse effects were minimal and could be easily managed; no adverse foetal effect was noted with the use of any drug in this study. Key Words: Clonidine, Fentanyl, Midazolam, Hypotention Preloading. Introduction: Discovery of benzodiazepine receptors in Considering the special group of patients spinal cord triggered the use of intrathecal Midazolam (Mothers) undergoing caesarean section, it is moral for analgesia (Mohler Okada, 1977). Several respons