CONGENITAL TOXOPLASMA GONDII INFECTION.docVIP

REVIEWS CONGENITAL TOXOPLASMA GONDII INFECTION Nazan Dalg?? Harvard University, Children’s Hospital Boston, Division of Infectious Diseases, Boston, ABD. ABSTRACT Pregnant women who acquire infection from Toxoplasma gondii usually remain asymptomatic, although they can still transmit the infection to their fetuses with severe consequences. Transmission of T. gondii to the fetus can result in serious health problems, including mental retardation, seizures, blindness, and death. Some health problems may not become apparent until the second or third decade of life. Serologic tests are used to diagnose acute T. gondii infection in pregnant women. Because false-positive tests occur frequently, serologic diagnosis must be confirmed at a Toxoplasma reference laboratory before treatment with potentially toxic drugs is considered. In many instances, congenital toxoplasmosis can be prevented by educating pregnant women and other women of childbearing age about not ingesting raw or undercooked meat, using measures to avoid cross-contamination of other foods with raw or undercooked meat, and protecting themselves against exposure to cat litter or contaminated soil. Keywords: Toxoplasma gondii, Congenital infection, Diagnosis, Treatment, Follow-up KONJEN?TAL TOXOPLASMA GOND?? ENFEKS?YONU ?ZET Hamile kad?nlar Toxoplasma gondii enfeksiyonunu genellikle asemptomatik olarak ge?irmelerine ra?men bebeklerini enfekte ederek onlarda bu enfeksiyona ba?l? ciddi sekellere neden olurlar. T. gondii enfeksiyonu fetusda mental retardasyon, havale, k?rlük ve ?lüm gibi ciddi sa?l?k problemleri ile sonu?lan?r. Bu sa?l?k problemlerinden baz?lar? 20`li ve 30`lu ya?lara kadar ortaya ??kmayabilir. Gebede akut T. gondii enfeksiyonu tan?s?nda serolojik testler kullan?l?r. Bu testlerde s?kl?kla yalanc? pozitif sonu?lara rastlan?l?r. Bu nedenle potansiyel toksik etkileri olan ila?larla tedaviye baslamadan ?