Connecting Chromatin Modifying Factors to DNA Damage Response.docVIP

Int. J. Mol. Sci. 2013, 14, 2355-2369; doi:10.3390/ijmOPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Connecting Chromatin Modifying Factors to DNA Damage Response Weiwei Lai 1,2,3, Hongde Li 1,2,3, Shuang Liu 4,5,* and Yongguang Tao 1,2,3, * 1 Cancer Research Institute, Central South University, Changsha 410078, Hunan, China; E-Mails: weiwater235@ (W.L.), azbyccx@163.com (H.L.) Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Changsha 410078, Hunan, China 2 3 4 Key Laboratory of Carcinogenesis Principal, Ministry of Health, Changsha 410078, Hunan, China Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China 5 Center for Medicine Science, Xiangya Hospital, Central South University, Changsha 410008, Hunan, China * Authors to whom correspondence should be addressed; E-Mails: liushuang1999@ (S.L.); taoyong@ (Y.T.); Tel.: +86-731-8447-0589. Received: 24 September 2012; in revised form: 11 December 2012 / Accepted: 9 January 2013 / Published: 24 January 2013 Abstract: Cells are constantly damaged by factors that can induce DNA damage. Eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin during the DNA damage response (DDR). Chromatin-remodeling complexes use the energy from ATP hydrolysis to remodel nucleosomes and have well-established functions in transcription. Emerging lines of evidence indicate that chromatin-remodeling complexes are important and may remodel nucleosomes during DNA damage repair. New studies also reveal that ATP-dependent chromatin remodeling is involved in cell cycle progression, signal transduction pathways, and interaction and modification of DDR-related proteins that are specifically and intimately connected with the process of DNA damage. This article summarizes the recent advances in our understanding of the