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CoryneRegNet An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks.doc

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CoryneRegNet An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

BMC Genomics BioMedCentral Database Open Access CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks Jan Baumbach1,2, Karina Brinkrolf1,3, Lisa F Czaja3, Sven Rahmann2 and Andreas Tauch*3 Address: 1International NRW Graduate School in Bioinformatics and Genome Research, Centrum für Biotechnologie, Universit?t Bielefeld, Universit?tsstra?e 25, D-33615 Bielefeld, Germany, 2Algorithms and Statistics for Systems Biology Group, Genome Informatics, Technische Fakult?t, Universit?t Bielefeld, Universit?tsstra?e 25, D-33615 Bielefeld, Germany and 3Institut für Genomforschung, Centrum für Biotechnologie, Universit?t Bielefeld, Universit?tsstra?e 25, D-33615 Bielefeld, Germany Email: Jan Baumbach - Jan.Baumbach@CeBiTec.Uni-Bielefeld.DE; Karina Brinkrolf - Karina.Brinkrolf@Genetik.Uni-Bielefeld.DE; Lisa F Czaja - liczaja@Genetik.Uni-Bielefeld.DE; Sven Rahmann - Sven.Rahmann@CeBiTec.Uni-Bielefeld.DE; Andreas Tauch* - Andreas.Tauch@Genetik.Uni-Bielefeld.DE * Corresponding author Published: 14 February 2006 Received: 11 November 2005 Accepted: 14 February 2006 BMC Genomics 2006, 7:24 doi:10.1186/1471-2164-7-24 This article is available from: /1471-2164/7/24 ? 2006 Baumbach et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silic