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Daily low-dose cisplatin and concurrent thoracic irradiation for poor-risk patients with unresectable non-small-cell lung cancer..doc

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Daily low-dose cisplatin and concurrent thoracic irradiation for poor-risk patients with unresectable non-small-cell lung cancer.

ActaMed.Okayama,2002 Vol.56,No.5,pp.261-266 Copyrightｃ2002byOkayamaUniversityMedicalSchool. Original Article http: //www.lib.okayama-u.ac.jp/www/acta/ DailyLow-DoseCisplatinandConcurrentThoracic IrradiationforPoor-RiskPatientswith UnresectableNon-Small-CellLungCancer IchiroTakata,HiroshiUeoka,KatsuyukiKiura,MasahiroTabata, NagioTakigawa,HidekiKatayama,MitsuhiroTakemoto, YoshioHiraki,MineHarada,andMitsuneTanimoto DepartmentofHematology,OncologyandRespiratoryMedicine, DepartmentofRadiology,OkayamaUniversityGraduateSchoolofMedicineandDentistry, Okayama700-8558,Japan,andMedicineandBiosystemicScience,InternalMedicine, MedicineandSurgery,KyushuUniversityGraduateSchoolofMedicalSciences,Fukuoka812-8582,Japan Apilotstudywasconductedtoassesstheecacyandfeasibilityofdailylow-dosecisplatinwith concurrentthoracicirradiationforclinicallyunresectablenon-small-celllungcancer(NSCLC). PatientswithinoperableNSCLCwhohadpoorriskfactorssuchasadvancedage,poorperformance status,poorlungfunction,orconcomitantactivemalignancywereenteredintothestudy. Low-dosecisplatin(6mg/m)wasadministereddailybeforeconcurrentthoracicirradiation(2Gy/ day;totaldoseof60Gy)wasgiven.Twenty-?vepatientswereregistered.Themajorityofthe patientshadeitherstageIIIA(24.0 )orstageIIIB(60.0 )disease.Fifteenpatients(60.0 ) completedtheplannedtreatment.Bothchemotherapyandradiotherapywerestoppedin3patients (12.0 )duetopoorresponse,and7patients(28.0 )partlyreceivedradiotherapyaloneasaresult oftheirtoxicityresponse.Theproportionoftotaladministereddosetoplanneddosewas90.9 for chemotherapyand99.3 forradiotherapy,whichwerecomparabletothoseinpreviousstudiesfor LA-NSCLCpatientswithoutpoorriskfactors.Grade3leukopeniaandneutropeniadevelopedin14 patients(56.0 )and10patients(40.0 ),respectively,butgrade4toxicitywasnotencountered. Grade3pneumonitisandesophagitiswereobservedin4patients(16.0 )and2patients(8.0 ), respectively.Theoverallresponseratewas60.0 .Themediansurvivaltimewas22months,andthe 2-yearsurvivalratewas50.3