Effective suppression of Dengue fever virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome.docVIP

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Effective suppression of Dengue fever virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome.doc

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Effective suppression of Dengue fever virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome

Virology Journal BioMedCentral Research Open Access Effective suppression of Dengue fever virus in mosquito cell cultures using retroviral transduction of hammerhead ribozymes targeting the viral genome Pruksa Nawtaisong1,2, James Keith1, Tresa Fraser1, Velmurugan Balaraman1, Andrey Kolokoltsov3, Robert A Davey3, Stephen Higgs4, Ahmed Mohammed1, Yupha Rongsriyam2, Narumon Komalamisra2 and Malcolm J Fraser Jr*1 Address: 1Department of Biological Sciences, Eck Institute of Global Health, University of Notre Dame, Notre Dame, Indiana 46556, USA, 2Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 3Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, 77555, USA and 4Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, 77555, USA Email: Pruksa Nawtaisong - eightam@; James Keith - jkeith@; Tresa Fraser - fraser.4@; Velmurugan Balaraman - vbalaram@; Andrey Kolokoltsov - aakoloko@; Robert A Davey - radavey@UTMB.EDU; Stephen Higgs - sthiggs@UTMB.EDU; Ahmed Mohammed - amohoammed00@; Yupha Rongsriyam - r_yupha@; Narumon Komalamisra - fraser.1@; Malcolm J Fraser* - fraser.1@ * Corresponding author Published: 4 June 2009 Received: 6 August 2008 Accepted: 4 June 2009 Virology Journal 2009, 6:73 doi:10.1186/1743-422X-6-73 This article is available from: /content/6/1/73 ? 2009 Nawtaisong et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Outbreaks of Dengue impose a heavy economic burden on developing countries in terms of vector control and human morbidity. Effective vaccines against all four serotypes of Dengue are in development, but