Effects of Heme Oxygenase-1 Upregulation on Blood Pressure and Cardiac Function in an Animal Model of Hypertensive Myocardial Infarction.docVIP

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Effects of Heme Oxygenase-1 Upregulation on Blood Pressure and Cardiac Function in an Animal Model of Hypertensive Myocardial Infarction.doc

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Effects of Heme Oxygenase-1 Upregulation on Blood Pressure and Cardiac Function in an Animal Model of Hypertensive Myocardial Infarction

Int. J. Mol. Sci. 2013, 14, 2684-2706; doi:10.3390/ijmOPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Effects of Heme Oxygenase-1 Upregulation on Blood Pressure and Cardiac Function in an Animal Model of Hypertensive Myocardial Infarction Tian-meng Chen 1,2,?, Jian Li 1,?, Lin Liu , Li Fan , Xiao-ying Li , Yu-tang Wang 1, 1 1 1 3 Nader G. Abraham and Jian Cao 1,* 1 First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing 100853, China; E-Mails: mengminami@ (T.C.); li_yinh@ (J.L.); bjll715@126.com (L.L.); fl6698@163.com (L.F.); lixy301@ (X.L.); wyt301@ (Y.W.) 2 School of Medicine, Nankai University, Tianjin 300071, China 3 Marshall University Joan C. Edward School of medicine, 1600 Medical Center Drive, Huntington, WV 25701, USA; E-Mail: abrahamn@M ? These authors contributed equally to this work. * Author to whom correspondence should be addressed; E-Mail: calvin301@163.com; Tel.: +86-10-6687-6231; Fax: +86-10-6814-2494. Received: 19 November 2012; in revised form: 6 January 2013 / Accepted: 21 January 2013 / Published: 28 January 2013 Abstract: In this study, we evaluate the effect of HO-1 upregulation on blood pressure and cardiac function in the new model of infarct spontaneous hypertensive rats (ISHR). Male spontaneous hypertensive rats (SHR) at 13 weeks (n = 40) and age-matched male Wistar (WT) rats (n = 20) were divided into six groups: WT (sham + normal saline (NS)), WT (sham + Co(III) Protoporphyrin IX Chloride (CoPP)), SHR (myocardial infarction (MI) + NS), SHR (MI + CoPP), SHR (MI + CoPP + Tin Mesoporphyrin IX Dichloride (SnMP)), SHR (sham + NS); CoPP 4.5 mg/kg, SnMP 15 mg/kg, for six weeks, one/week, i.p., n = 10/group. At the sixth week, echocardiography (UCG) and hemodynamics were performed. Then, blood samples and heart tissue were collected. Copp treatment in the SHR (MI + CoPP) group lowered blood p