Effects of dietary CoQ10 and α-lipoic acid on CoQ10 levels in plasma and tissues of eggs laying hens.docVIP

J. Biomedical Science and Engineering, 2013, 6, 185-191 JBiSE /10.4236/jbise.2013.62022 Published Online February 2013 (/journal/jbise/) Effects of dietary CoQ and α-lipoic acid on CoQ levels 10 10 in plasma and tissues of eggs laying hens Petra Jazbec Krizman, Andrej Smidovnik, Alenka Golc Wondra, Mitja Krizman, Mirko Prosek National Institute of Chemistry, Ljubljana, Slovenia Email: andrej.smidovnik@ki.si Received 17 December 2012; revised 17 January 2013; accepted 23 January 2013 ABSTRACT tion especially in liver and heart tissues. In this paper we described the effect of administrated CoQ , and alfa-lipoic acid on the concentration of 10 Keywords: Laying Hens; Coenzyme Q ; α-Lipoic Acid; Antioxidant Network; Fodder Additive 10 total CoQ10 in plasma end body tissues of eggs laying hens. Organisms raise a complex network of enzymes, metabolites and molecules with antioxidant activities in order to prevent oxidative damage of theirs bodies. Adequate blood concentrations of small weight mole- cules ingested with food and food additives are im- portant for the proper functioning of the antioxidant defense. To test this hypothesis we prepared following experiment. Forty weeks old hens were selected from two genotypes; Ross 308 broiler mothers and Loh- mann breed hens. Animals were fed for a period of 84 1. INTRODUCTION Living organisms have to raise a complex system of en- zymes, metabolites and molecules with antioxidant ac- tivities in order to prevent oxidative damage of theirs bodies [1,2]. Until recently, scientists believed that each antioxidant worked separately, independently of the oth- ers. Research performed at the Packer Lab at the Univer- sity of California at Berkeley showed that there is a dy- namic connection among certain key antioxidants. These special antioxidants operate together and represent a dy- namic defense of an organism. Antioxidants in this net- work terminate o