Effects of different doses of dexamethasone plus flunixin meglumine on survival rate in lethal endotoxemia.docVIP

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Effects of different doses of dexamethasone plus flunixin meglumine on survival rate in lethal endotoxemia.doc

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Effects of different doses of dexamethasone plus flunixin meglumine on survival rate in lethal endotoxemia

ActaVeterinaria(Beograd),Vol.59,No.1,47-51,2009. DOI:10.2298/AVB0901047E UDK619.615.276 EFFECTSOFDIFFERENTDOSESOFDEXAMETHASONEPLUSFLUNIXINMEGLUMINEON SURVIVALRATEINLETHALENDOTOXEMIA ERA*,UNEYK*,ALTANF**,CETING*,YAZARE*andELMASM* *UniversityofSelcuk,FacultyofVeterinaryMedicine,DepartmentofPharmacologyandToxicology, Campus,Konya,Turkey **UniversityofDicle,FacultyofVeterinaryMedicine,DepartmentofPharmacologyandToxicology, Campus,Diyarbakir,Turkey (Received4.April2008) Effects of different doses of dexamethasone plus flunixin meglumineonsurvivalratewereinvestigatedinlethalendotoxemia.A totalof60Balb/Cfemalemiceweredividedinto4equalgroups.Lethal endotoxemia(80-100%)wasinducedbylipopolysaccharideinjection (Group 1, 1 mg, intraperinoneally). At 4 hours after the lipopoly- saccharide injection; low-dose dexamethasone (0.6 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously),normal-dosedexamethasone(2mg/kg,SID,5days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously) and high-dose dexamethasone (10 mg/kg, SID, 5 days, intramuscularly) + flunixin meglumine (2 mg/kg, SID, 5 days, subcutaneously)wereinjectedtoGroup2,3and4,respectively.After the injections, survival was monitored at 7 days and 13.3%, 13.3%, 33.3%and73.3%survivalrateswereobservedinGroups1,2,3and4, respectively. As results, high-dose dexamethasone plus flunixin meglumine may be the treatment of choice for endotoxaemia in animals. Key words: lethal endotoxaemia, dexamethasone, flunixin, survivalrate INTRODUCTION Septic shock is defined as sepsis-induced persistent hypotension accompaniedbyhypoperfusionabnormalitiesororgandysfunction.Themortality rateis50-60%insepticshock.Lipopolysaccharides(LPS)playacriticalroleinthe pathophysiology of septic shock (Annane et al., 2004; Sanchez, 2005). When microbes or their products (LPS) are present in the bloodstream, the same mechanisms that are beneficial in resolving a local infection become a