Effects of IL-17 on functional activity of peripheral blood cells.docVIP

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Effects of IL-17 on functional activity of peripheral blood cells.doc

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Effects of IL-17 on functional activity of peripheral blood cells

ActaVeterinaria(Beograd),Vol.54.No.4,249-261,2004. UDK619:612.112.6 EFFECTSOFIL-17ONFUNCTIONALACTIVITYOFPERIPHERALBLOODCELLS VLA[KIMARIJA,KRSTI]ALEKSANDRA,JOV^I]GORDANA,BUGARSKIDIANA, PETAKOVMARIJANA,STOJANOVI]NEVENKAandMILENKOVI]P InstituteforMedicalResearch,Belgrade (Received4.April2004) Interleukin-17 (IL-17) is a proinflammatory cytokine produced mainlybyactivatedCD4+andCD8+Tcells,whileitsspecificreceptor isubiquitouslydistributed.TheinflammatorycapacityofIL-17isbased onitsabilitytostimulateawiderangeofstromalcellstoproduceand release a number of proinflammatory mediators, some with a known impact on hematopoiesis, particularly granulopoiesis. Recent data indicate a role for IL-17 in the pathogenesis of several inflammatory diseases, transplant rejection and tumor growth. The purpose of this studywastodeterminefunctionalresponses,includingtherespiratory burst, nitric oxide (NO) production, adhesiveness and metabolical activity/viabilityofhumanperipheralbloodleukocytes(totalwhiteblood cells,mononuclearcellsandgranulocytes)fromhealthydonorsinthe presence of recombinant human (rh)IL-17. The obtained results showed that rhIL-17 did not induce significant changes in the respiratory burst, NO production, and metabolical activity of each peripheral blood cell fraction the tested, while a slight increase in phorbol-12-myristate-13-acetate (PMA) stimulated adhesiveness of granulocytes and mononuclear cells was noted. The absence of significantchangesintestedfunctionalactivitiesofvariousperipheral blood cells suggests that IL-17 does not express its proinflammatory abilityinsteady-state,sincetherequirementforitsactionreallydoesnot exist. Key words: cytokines, IL-17, inflammation, leukocyte functional activity INTRODUCTION IL-17isanewlydescribedcytokine,firstidentifiedasthehumanhomologof cytotoxicTlymphocyte-associatedantigen8,CTLA-8(Rouvieretal.,1993).Since CTLA-8displayedsomeofthefeaturesofcytokinegenes,suchasthepredicted hydrophobicNH -terminalsequencewhichcouldcor