Automatic Quantitative MRI Texture Analysis in Small-for-Gestational-Age Fetuses Discriminates Abnormal Neonatal Neurobehavior.docVIP

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Automatic Quantitative MRI Texture Analysis in Small-for-Gestational-Age Fetuses Discriminates Abnormal Neonatal Neurobehavior.doc

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Automatic Quantitative MRI Texture Analysis in Small-for-Gestational-Age Fetuses Discriminates Abnormal Neonatal Neurobehavior

AutomaticQuantitativeMRITextureAnalysisinSmall- for-Gestational-AgeFetusesDiscriminatesAbnormal NeonatalNeurobehavior MagdalenaSanz-Cortes1,2,3*,GiuseppeA.Ratta1,2,3,FrancescFigueras1,2,3,ElisendaBonet-Carne1,2,3 , NellyPadilla1,2,3,AngelaArranz1,2,3,NuriaBargallo4,5,EduardGratacos1,2,3 1Maternal-Fetal Medicine Department, ICGON, Hospital Cl?nic, Universitat de Barcelona, Barcelona, Spain, 2Fetal and Perinatal Medicine Research Group, Institut d’InvestigacionsBiomediquesAugustPiiSunyer(IDIBAPS),Barcelona,Spain,3CentrodeInvestigacio′nBiome′dicaenReddeEnfermedadesRaras(CIBERER),Barcelona, Spain,4DepartmentofRadiologyHospitalClinic,CentredeDiagnosticperlaImatge,HospitalCl?′nic,Barcelona,Spain,5ImageplatformIDIBAPS,Barcelona,Spain Abstract Background: Wetestedthehypothesiswhethertextureanalysis(TA)fromMRimagescouldidentifypatternsassociated withanabnormalneurobehaviorinsmallforgestationalage(SGA)neonates. Methods: Ultrasound and MRI were performed on 91 SGA fetuses at 37weeks of GA. Frontal lobe, basal ganglia, mesencephalonandcerebellumweredelineatedfromfetalMRIs.SGAneonatesunderwentNBAStestandwereclassifiedas abnormal if $1 area was ,5th centile and as normal if all areas were .5th centile. Textural features associated with neurodevelopmentwereselectedandmachinelearningwasusedtomodelapredictivealgorithm. Results:Ofthe91SGAneonates,49wereclassifiedasnormaland42asabnormal.Theaccuraciestopredictanabnormal neurobehaviorbasedonTAwere95.12%forfrontallobe,95.56%forbasalganglia,93.18%formesencephalonand83.33% forcerebellum. Conclusions:FetalbrainMRItexturalpatternswereassociatedwithneonatalneurodevelopment.BrainMRITAcouldbea usefultooltopredictabnormalneurodevelopmentinSGA. Citation:Sanz-CortesM,RattaGA,FiguerasF,Bonet-CarneE,PadillaN,etal.(2013)AutomaticQuantitativeMRITextureAnalysisinSmall-for-Gestational-Age FetusesDiscriminatesAbnormalNeonatalNeurobehavior.PLoSONE8(7):e69595.doi:10.1371/journal.pone.0069595 Editor:GrainneM.McAlonan,King’sCollegeLondon,UnitedKingdom Receiv