Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model.docVIP

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Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model.doc

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Bee Venom and Its Component Apamin as Neuroprotective Agents in a Parkinson Disease Mouse Model

BeeVenomandItsComponentApaminas NeuroprotectiveAgentsinaParkinsonDiseaseMouse Model DanielAlvarez-Fischer1,2,3,4,5,8,9 .,CarmenNoelker1,2,3,4,5.,FrancaVulinovic′8,AnneGru¨newald8, CarolineChevarin6,ChristineKlein8,WolfgangH.Oertel5,EtienneC.Hirsch1,2,3,4,PatrickP.Michel1,2,3,4 , AndreasHartmann1,2,3,4,7 * 1Universite′PierreetMarieCurie-Paris6,UMR_S975-UMR7725,CentredeRechercheenNeurosciences,ICM,TherapeutiqueExperimentaledelaNeurodegenerescence, Paris,France,2Inserm,U975,CentredeRechercheenNeurosciences,ICM,TherapeutiqueExperimentaledelaNeurodegenerescence,Paris,France,3CNRS,UMR7225, Centre de Recherche en Neurosciences, ICM, Therapeutique Experimentale de la Neurodegenerescence, Paris, France, 4ICM, Therapeutique Experimentale de la Neurodegenerescence,Paris,France,5DepartmentofNeurology,Philipps-UniversityMarburg,Marburg,Germany,6Unite′ MixtedeRechercheS677,Universite′ Pierreet Marie Curie-Paris 6, Paris, France, 7De′partement de Neurologie, Po?le des Maladies du Syste`me Nerveux, Ho?pital de la Pitie′-Salpe?trie`re, Paris, France, 8Institute of Neurogenetics,UniversityofLu¨beck,Lu¨beck,Germany, 9DepartmentofPsychiatry,UniversityofLu¨beck,Lu¨beck,Germany Abstract Bee venom has recently been suggested to possess beneficial effects in the treatment of Parkinson disease (PD). For instance,ithasbeenobservedthatbilateralacupointstimulationoflowerhindlimbswithbeevenomwasprotectiveinthe acute1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)mousemodelofPD.Inparticular,aspecificcomponentofbee venom, apamin, has previously been shown to have protective effects on dopaminergic neurons in vitro. However, no informationregardingapotentialprotectiveactionofapamininanimalmodelsofPDisavailabletodate.Thespecificgoals ofthepresentstudywereto(i)establishthattheprotectiveeffectofbeevenomfordopaminergicneuronsisnotrestricted to acupoint stimulation, but can also be observed using a more conventional mode of administration and to (ii) demonstratethatapamincanmimictheprotec