Beta-adrenergic receptor polymorphisms A basis for pharmacogenetics.docVIP

World Journal of Cardiovascular Diseases, 2013, 3, 406-411 WJCD /10.4236/wjcd.2013.36063 Published Online September 2013 (/journal/wjcd/) Beta-adrenergic receptor polymorphisms: A basis for pharmacogenetics Efstratios K. Theofilogiannakos , Konstantinos Dean Boudoulas , Brian E. Gawronski , 1* 2* 3 1 1 3 Taimour Y. Langaee , Timotheos G. Kelpis , Antonios A. Pitsis , Julie A. Johnson , 3 2,4# Harisios Boudoulas 1 2 3 Agios Lukas Hospital, Thessaloniki, Greece The Ohio State University, Division of Cardiovascular Medicine, Columbus, Ohio, USA University of Florida, Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, Gainesville, Florida, USA Aristotelian University of Thessaloniki, Thessaloniki, Greece 4 Email: boudoulas@bioacademy.gr # Received 28 May 2013; revised 1 July 2013; accepted 16 July 2013 Copyright ? 2013 Efstratios K. Theofilogiannakos et al. This is an open access article distributed under the Creative Commons At- tribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is prop- erly cited. ABSTRACT Greek population are similar to those of other Euro- pean ancestry, and less common than in those of Af- rican origin indicating variability in ethnic groups. This information provides insight into common po- lymorphisms that may assist in optimizing β-anta- gonist and agonist therapy. Aims: Polymorphisms of the β-adrenergic receptor, the frequency of which may differ in ethnic groups, alters β-receptor function. The aim of this study was to elucidate the frequency of β1 and β2-adrenergic receptor polymorphisms in healthy Greeks and to compare with those