Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis 英文论文文献.docVIP

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Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis 英文论文文献.doc

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis 英文论文文献

Garay-Malpartidaetal.BMCImmunology2011,12:18 /1471-2172/12/18 RESEARCH ARTICLE OpenAccess Toll-likereceptor4(TLR4)expressioninhuman andmurinepancreaticbeta-cellsaffectscell viabilityandinsulinhomeostasis HumbertoMGaray-Malpartida1,2,RobertaFMour?o1,MarluceMantovani1,3,IcaroASantos1,MariCSogayar1,3, AnnaCGoldberg1,4,5* Abstract Background:Toll-likereceptor4(TLR4)iswidelyrecognizedasanessentialelementinthetriggeringofinnate immunity,bindingpathogen-associatedmoleculessuchasLipopolysaccharide(LPS),andininitiatingacascadeof pro-inflammatoryevents.EvidenceforTLR4expressioninnon-immunecells,inclu

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