pH值对甲硝唑葡萄糖注射液稳定性的影响.pdfVIP

# 12 # 安 徽 医 药 A nh ui M ed ical and P har maceut ical Jour nal 2002 Jun; 6( 2) 1 pH 值对甲硝唑葡萄糖注射液稳定性的影响 ( 安徽省安庆市立医院, 安庆 246003) pH pH 5- pH 4100~ 4140 , pH 41 00~ 4140 ; ; pH ; 5- Effects of pH value on the stability of Metronidazole and Glucose Injection PAN Bing-Hui ( A nqi ng M un icip al H osp i tal, A nqing 246003) ABSTRACT AIM T o study the effe ts of intermediate pH of Metronidazole and Glu ose Inje tion during preparation pro ess on it. s main quality indexes. METHOD The quantity of metronidazole, Glu ose, pH and 5-hy droxymethylfurfual in the final produ tion w ere determined w hen pH of intermediates w as ontrolled betw een 4100~ 6100. RES LT T he qualit y of metronidazole and Glu ose Inje tion was stable w hen pH of intermediates w as between 4100~ 4140. CONCL SION The intermediates pH should be betw een 4100~ 4140 during preparation pro ess. KEY WORDS metronidazole; Glu ose; pH; 5-hydroxymet hylfurfual 12 2 pH 5- 5-HMF 012 g , 100 ml, 11, 2 2 ( 5-HMF) 01 101201 3014015 ml, 100 ml , pH , , , , 280 nm350 nm pH , , A280 - A350 $A , pH , C= 71 789 2 $! ? 01 006 4, r = 01999 8 $A $A pH $pH 5- 2 ml, 50 ml , 1 HMF C, pH , , $A , 5-HMF C( mg# pH L- 1) 1 x…? s , t , , 200101