_急性白血病患者血清乳酸脱氢酶与α-羟丁酸脱氢酶变化的临床意义.pdfVIP

·406 · 疑难病杂志2007 年7 月第6 卷第7 期　Chin J Diffic and Compl Cas, July 2007, Vol.6 No.7 ·论　著· 急性白血病患者血清乳酸脱氢酶与α-羟丁 酸脱氢酶变化的临床意义 周守勤　刘敏 　　【摘　要】　目的　研究血清乳酸脱氢酶(LDH )与α-羟丁酸脱氢酶(α-HBDH)的变化与急性白血病 (AL)患者疗效、预后的关系。 方法　用全自动生化分析仪检测 56 例初发或复发AL 患者治疗前后血清 LDH 与α-HBDH 浓度。 同时纳入健康体检者35 例为健康对照组, 观察比较2 组 LDH、α-HBDH 含量。 结 果　AL 患者血清LDH 及α-HBDH 初发或复发时明显增高, 与健康对照组比较差异有非常显著统计学意 义(P0.01);治疗后达完全缓解与部分缓解者LDH 和α-HBDH 含量下降, 治疗前后比较差异有统计学 意义(P0.01);复发后较复发前有明显上升(P0.01);外周血幼稚细胞绝对数与血清LDH 和α-HB- DH 含量呈正相关(r 值分别为0.558 7 和0.541 1, P0.01)。 结论　动态检查血清LDH 及α-HBDH 变 化有助于监测AL 患者的病情变化, 高水平血清LDH 及α-HBDH 提示预后差。 【关键词】　白血病, 急性;乳酸脱氢酶;α-羟丁酸脱氢酶 【中图分类号】　R 382.11;R 733.71　【文献标识码】　A　【文章编号】　1671-6450(2007)07-0406-03 Clinical significance of serum lactic dehydrogenase and α-hydroxybuty rate dehydrogenase in patients with acute leukemia　ZHOU Shou-qin, LIU Min.Department of Clinical Laboratory, Tangshan Steel Corporation eneral Hospital, Hebei, Tangshan　063020, China 【Abstract】　Obj ective 　To inves iga e he clinical significance of he changes of serum lac ic dehydrogenase (LDH )and α-hydroxybu yra e dehydrogenase (α-HBDH)in pa ien s wi h acu e leukemia (AL).Methods　The se- rum samples w ere collec ed from 56 pa ien s wi h acu e leukemia including 44 primary onse pa ien s and 12 relapsed pa ien s, and 35 heal hy subjec s w ere u sed as con rol group.LDH and α-HBDH w ere de ec ed by enzyma ic assay. Results　The levels of LDH and α-HBDH w ere signif ican ly higher in newly diagnosed pa ien s and relapsed pa ien s han hose in con rol group (P0.01).The concen ra ions of bo h enzymes w ere decreased in comple e remission pa ien s and par ial remission pa ien s af er rea men , here was a signif ican difference before chemo herapy and af er chemo herapy (P 0.01).The concen ra ions of LDH and α-HBDH were obviously increased af er relapsing, as compared wi h