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Cellular Signalling 27 (2015) 2515–2523 Contents lists available at ScienceDirect Cellular Signalling journal homepage: /locate/cel lsi g DAB2IP regulates the chemoresistance to pirarubicin and tumor recurrence of non-muscle invasive bladder cancer through STAT3/Twist1/P-glycoprotein signaling Kaijie Wu a,1, Bin Wang a,1, Yule Chen a, Jiancheng Zhou a, Jun Huang a, Ke Hui a, Jin Zeng a, Jianning Zhu a, Kai Zhang a, Lei Li a, Peng Guo a, Xinyang Wang a, Jer-Tsong Hsieh b, Dalin He a,⁎, Jinhai Fan a,⁎ a Department of Urology, First Affi liated Hospital of Xian Jiaotong University, Xian 710061, PR China b Department of Urology, University of Texas Southwestern Medical Center, Dallas 75390, TX, USA a r t i c l e i n f o a b s t r a c t Article history: There is a high frequency of tumor recurrence in non-muscle invasive bladder cancer (NMIBC) after transurethral Received 16 September 2015 resection and postoperative intravesical chemotherapy, however, the molecular mechanisms leading to the Accepted 23 September 2015 chemoresistance and tumor re-growth remain largely unknown. In this study, we observed a significant decrease Available online 26 September 2015 of DAB2IP expression in high-grade and recurrent NMIBC specimens, which was negatively correlated with Twist1 expression and predicted a lower recurrence-free survival of patients. Mechanistically, DAB2IP could Keywords: Bladder cancer inhibit the phosphorylati