A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease英文文献资料.docVIP

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A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease英文文献资料.doc

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A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease英文文献资料

HindawiPublishingCorporation Evidence-BasedComplementaryandAlternativeMedicine Volume2012,ArticleID519031,15pages doi:10.1155/2012/519031 ResearchArticle ASystemsBiologyApproachto UncoveringPharmacologicalSynergyinHerbalMedicineswith ApplicationstoCardiovascularDisease XiaWang, XueXu, WeiyangTao, YanLi, 1 1 1 2YonghuaWang,1,3andLingYang4 1 2 3 4 CenterofBioinformatics,CollegeofLifeScience,NorthwestAFUniversity,Yangling,Shaanxi712100,China SchoolofChemicalEngineering,DalianUniversityofTechnology,Dalian,Liaoning116024,China InstituteofChineseMateriaMedica,ChinaAcademyofChineseMedicalSciences,Beijing100700,China LaboratoryofPharmaceuticalResourceDiscovery,DalianInstituteofChemicalPhysics,ChineseAcademyofSciences, Dalian116023,China CorrespondenceshouldbeaddressedtoYonghuaWang,yhwang@ Received19August2012;Accepted10October2012 AcademicEditor:KashmiraNanji Copyright?2012XiaWangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Background.Clinicaltrialsrevealthatmultiherbprescriptionsofherbalmedicineoftenexhibitpharmacologicalandtherapeutic superiorityincomparisontoisolatedsingleconstituents.However,thesynergisticmechanismsunderlyingthisremainelusive.To addressthisquestion,anovelsystemsbiology modelintegratingoralbioavailabilityanddrug-likenessscreening,targetiden- ti?cation,andnetworkpharmacologymethodhasbeenconstructedandappliedtofourclinicallywidelyusedherbsRadixAstragali Mongolici,RadixPuerariaeLobatae,RadixOphiopogonisJaponici,andRadixSalviaeMiltiorrhizawhichexertsynergistice?ects ofcombinedtreatmentofcardiovasculardisease(CVD).Results.Theresultsshowthatthestructuralpropertiesofmoleculesin fourherbshavesubstantialdi?erences,andeachherbcaninteractwithsigni?canttargetproteinsrelatedtoCVD.Moreover,the bioactiveingredientsfromdi?erentherbspotentiallyactonthesamemoleculartarget(multiple-drug-one-targ