Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens英文文献资料.docVIP

Vol.1, No.1, 28-33 (2012) Journal of Agricultural Chemistry and Environment /10.4236/jacen.2012.11005 Analysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens Dong Gu Lee 1 , So-Youn Mok 1 , Changsun Choi 2 3 4 , Eun Ju Cho , Hyun Young Kim , Sanghyun Lee 1* 1 * 2 3 4 Department of Integrative Plant Science, Chung-Ang University, Anseong, South Korea; Corresponding Author: slee@cau.ac.kr Department of Food and Nutrition, Chung-Ang University, Anseong, South Korea Department of Food Science and Nutrition, Pusan National University, Busan, South Korea Department of Food Science, Gyeongnam National University of Science and Technology, Jinju, South Korea Received 31 August 2012; revised 3 October 2012; accepted 18 October 2012 ABSTRACT reported to have antifungal, antibacterial, antifebrile, anodyne, coryza, fever, influenza, cough, and dyspepsia properties [7,8]. Furthermore, B. balsamifera has attrac- ted attention as a medicinal plant as it possesses various physiological activities such as anti-obesity [9], plasmin- inhibitory [1], anti-fungal [8], liver-protective [10], and anti-cancer effects [11]. To investigate the therapeutic potentials of na- tural sources, stepwise polarity fractions of Blu- mea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat len- ses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 Investigation of phytochemical constituents from B. balsamifera showed significant amounts of flavones, mo- noterpenes and triterpenes [12-14]. Fazilatun et al. [14, 15] reported the isolation of velutin and dihydroquerce- tin-7,40-dimethylether from pet-ether extracts; blumeatin and luteolin-7-methylether from the chloroform extracts; and ombuine, tamarixetin, rhamnetin, luteolin,