Analysis of candidate genes of QTL and chromosomal regions for essential hypertension in the rat model英文文献资料.docVIP

Open Journal of Genetics, 2012, 2, 136-154 OJGen /10.4236/ojgen.2012.23019 Published Online September 2012 (http://www.SciRP.org/journal/ojgen/) Analysis of candidate genes of QTL and chromosomal regions for essential hypertension in the rat model Lishi Wang , Jiaqian Zhu , Yue Huang , Qing Xiong , Cong-Yi Wang , Arnold Postlethwaite , 1,2 1,3 1 4 5 6 7 1* Yongjun Wang , Weikuan Gu 1 Departments of Orthopaedic Surgery-Campbell Clinic and Pathology, University of Tennessee Health Science Center (UTHSC), Memphis, USA 2 3 4 5 6 7 Department of Basic Medicine, Inner Mongolia Medical University, Huhhot City, China Rust College, Holly Spring, USA Department of Biostatistics and Bioinformatics, Duke University, Durham, USA Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, USA Department of Medicine, University of Tennessee Health Science Center (UTHSC), Memphis, USA Department of Neurology, Beijing Tiantan Hospital, Capital University of Medical Sciences, Beijing, China Email: Lwang37@, Jzhu@, hyue@, qxiong1@, cwang@, apostlet@, yongjunwang111@, * wgu@ Received 20 May 2012; revised 25 June 2012; accepted 10 July 2012 ABSTRACT difficulties in studying genetic variations relating to hy- pertension in humans, researchers chose the rat as an ideal model. In recently review articles, progress for the genetic dissection of essential hypertension in humans using a rat model have been summarized. Cowley [5] pointed out that the next daunting task is gene identifica- tion and validation. Currently, more than 300 Quantitative trait loci (QTLs) for blood pressure and hypertension are reported in the rat genome (see the Rat Genome Database web site at: /), and these