Analysis of Mechanical Behavior of Red Blood Cell Membrane with Malaria Infection英文文献资料.docVIP

World Journal of Mechanics, 2011, 1, 100-108 doi:10.4236/wjm.2011.13014 Published Online June 2011 (http://www.SciRP.org/journal/wjm) Analysis of Mechanical Behavior of Red Blood Cell Membrane with Malaria Infection Vinod Kumar Katiyar, Demeke Fisseha Department of Mathematics, Indian Institute of Technology Roorkee, Roorkee, India E-mail: vktmafma@, demeke19@ Received March 22, 2011; revised April 20, 2011; accepted April 29, 2011 Abstract Human red blood cells (RBCs) are responsible to transport oxygen and carbon dioxide for human bodies. The physiological functions of RBCs are greatly influenced by their mechanical properties. When RBC is infected by Malaria parasite called Plasmodium falciparum, it shows progressive changes in mechanical properties and loses its deformability. The infected red blood cells (IRBCs) develop properties of cytoadher- ence (stickiness) and rosetting (the binding of non-infected RBCs to parasitized RBCs). In this paper to ana- lyze the mechanical properties and deformability of the IRBC, we applied stress-stretch ratio relation of its biomembrane .To express this constitutive relation, we proposed a mathematical model (Neo-Hookean model) based on membrane theory. On this model, we present continuous stress-stretch ratio curves for the relation derived from the model for different intracellular developmental stages of the parasite, to determine the mechanical properties of IRBC. The analytical results obtained from the mathematical model are more closed with the experimental data [1] which demonstrates the validity of the model. By restricting our atten- tion to spherically symmetric deformation in the final schizont stage of parasite development, the pres- sure-extension ratio relation curve also adapted from the proposed strain energy function. The change in os- motic pressure versus volumetric ratio has been also considered for IRBC before hemolysis. Keywords: Cell Mechanics, Malaria