Analytical solution of coupled non-linear second order differential equations in enzyme kinetics英文文献资料.docVIP

Vol.3, No.6, 459-465 (2011) Natural Science /10.4236/ns.2011.36063 Analytical solution of coupled non-linear second order reaction differential equations in enzyme kinetics Govindhan Varadharajan, Lakshmanan Rajendran Department of Mathematics, The Madura College, Madurai, India; raj_sms@ Received 16 April 2011; revised 10 May 2011; accepted 17 May 2011. ABSTRACT The generalized theoretical treatment of the tran- sient-state kinetics of enzyme reaction system described The coupled system of non-linear second-order reaction differential equation in basic enzyme reaction is formulated and closed analytical ex- pressions for substrate and product concentra- tions are presented. Approximate analytical me- thod (He’s Homotopy perturbation method) is used to solve the coupled non-linear differential equations containing a non-linear term related to enzymatic reaction. Closed analytical expres- sions for substrate concentration, enzyme sub- strate concentration and product concentration have been derived in terms of dimensionless reaction diffusion parameters k, ? and ? us- ing perturbation method. These results are compared with simulation results and are found to be in good agreement. The obtained results are valid for the whole solution domain. [5-9] under the conditions E remains effectively constant during ? ? ???S0? , the enzyme 0 concentration ?E? the course of the reaction and only the substrate concen- tration ?S? changes appreciably with time. The rate of second-order reactions in chemistry are frequeuntly stu- died within PFO kinetics [10,11]. Numerical studies of reaction (1) far from the QSS or equilibrium approxima- tions demonstrate that if the excess reactant concentra- ? ? :?S0? say, is less than 10-fold, apprecia- tion ratio E ble errors are introduced in the pseudo-first-order kinet- 0 ics description [7]. Silicio and Peterso