Analytical solution of the concentration and current in the electoenzymatic processes involved in a PPO-rotating-disk-bioelectrode英文文献资料.docVIP

Vol.3, No.1, 1-8 (2011) Natural Science /10.4236/ns.2011.31001 Analytical solution of the concentration and current in the electoenzymatic processes involved in a PPO-rotating-disk-bioelectrode Govindhan Varadharajan, Lakshmanan Rajendran * Department of Mathematics, The Madura college, Madurai, India; Corresponding Author: raj_sms@ * Received 16 October 2010; revised 20 November 2010; accepted 25 November 2010. ABSTRACT view of numerous application of such bio-sensor with amplified response, we are interested in investigating the concentration s and p in order to improve the metrologi- cal characteristics further. In addition, this theoretical approach is of practical interest since this kind of bio- sensor can be used for the determination of phenolic compounds and catecholamine neurotransmitters in the field of environmental control and clinical analysis [12- 22]. Such a theoretical and kinetic analysis is a powerful approach to rationalize functions of biosensors. Desprez and Labbe [23] obtained the analytical expression con- centration and current for the limiting cases only. The purpose of this communication is to derive a simple ac- curate polynomial expressions of concentrations gener- ated at a enzyme electrode using Homotopy perturbation method. A mathematical model for electroenzymatic process of a rotating-disk-bioelectrode in which polyphenol oxidase occurs for all values of concentration of catechol substrate is pre- sented. The model is based on system of reac- tion-diffusion equations containing a non-linear term related to Michaelis-Menten kinetics of the enzymatic reaction. Approximate analytical me- thod (He’s Homotopy perturbation method) is used to solve the non-linear differential equa- tions that describe the diffusion coupled with a Michaelis-Menten kinetics law. Closed analytical expressions for substrate concentration, prod- uct concentratio