Anti Inflammatory Effects of Statins in Cardiac Surgery Patients英文文献资料.docVIP

World Journal of Cardiovascular Surgery, 2012, 2, 40-47 /10.4236/wjcs.2012.23010 Published Online September 2012 (http://www.SciRP.org/journal/wjcs) Anti Inflammatory Effects of Statins in Cardiac Surgery Patients* Adnan Raza Thomas Murphy , Susan Kennedy , Yue Fan , Belinda Maher , Mary Codd , 1,2# 2 2 2 2 2 1 2 , Alfred Wood , William Watson 1 Eoin O’Malley National Centre for Cardiothoracic Surgery, Mater Misericordiae University Hospital, Dublin, Ireland UCD School of Medicine and Medical Sciences, Conway Institute, University College Dublin, Dublin, Ireland 2 Email: adnan_raza@ # Received May 16, 2012; revised June 30, 2012; accepted July 18, 2012 ABSTRACT Objectives: Cardiac surgery with cardiopulmonary bypass provokes systemic inflammatory response, which may cause organ dysfunction. Studies have suggested that pre-operative statin therapy can reduce morbidity and mortality associ- ated with cardiac surgery; the mechanism for this remains unclear. We hypothesise that underlying mechanism of action for these effects of statins is through inhibition of neutrophil transendothelial migration. Methods: We recruited 151 patients undergoing cardiac surgery. Of these 41 patients were on no-statin; 48 patients on low-dose (10 - 30 mg) and 62 patients were on high-dose statin (40 - 80 mg). Ex vivo neutrophil migration was performed on pre-operative blood samples of 90 patients. Of these 90 patients we used 36 patients to assess the levels of TNF-α and sICAM-1. Clinical parameters of total 151 patients were assessed to analyse outcome. Results: Ex vivo neutrophil migration was decreased in high-dose statin group when compared to neutrophils isolated from no-statin or low-dose statin groups (p 0.001). Serum TNF-