Anti-Amnesic Activity of Vitex Negundo in Scopolamine Induced Amnesia in Rats英文文献资料.docVIP

Pharmacology Pharmacy, 2010, 1, 1-8 1 10.4236/pp.2010.11001 Published Online July 2010 (http://www.SciRP.org/journal/pp) Anti-Amnesic Activity of Vitex Negundo in Scopolamine Induced Amnesia in Rats Abhinav Kanwal , Jogender Mehla , Madhusudana Kuncha , Vegi Ganga Modi Naidu , l,2 3 l l 3 1 Yogendra Kumar Gupta , Ramakrishna Sistla * 1 Division of Pharmacology, Indian Institute of Chemical Technology (IICT), Hyderabad, India; 2 National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, India; New Delhi, India. 3 Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Email: sistla@iict.res.in Received June 8 , 2010; accepted July 12 , 2010. th th ABSTRACT In the present study we investigated the anti-amnesic activity of Vitex negundo in scopolamine induced amnesia in rats. Wistar rats (180-200 g) were trained on active avoidance task. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. Scopolamine (3 mg/kg, i.p) was administered at different time periods on the basis of stages of memory i.e acquisition, consolidation and retention in different groups (n = 6). Effect of Vitex negundo extract was evaluated and compared to a standard drug, Donepezil. Significant (p 0.05) increase in the avoidance response on the 5 session has been observed as compared to 1 session in control group. Scopolamine treatment significantly (p th st 0.05) reduced the avoidance response compared to control. Extract treated groups shown significant (p 0.05) in- crease in number of