Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice英文文献资料.docVIP

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Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice英文文献资料.doc

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Anti-IL-6 Receptor Antibody Causes Less Promotion of Tuberculosis Infection than Anti-TNF- Antibody in Mice英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2011,ArticleID404929,9pages doi:10.1155/2011/404929 ResearchArticle Anti-IL-6ReceptorAntibodyCausesLessPromotionof TuberculosisInfectionthanAnti-TNF-αAntibodyinMice MasajiOkada, 1 YokoKita, 1 NorikoKanamaru, 1 SatomiHashimoto, 1 YasushiUchiyama, 2 MasahikoMihara, 2 YoshikazuInoue, 1 YoshiyukiOhsugi, 2 TadamitsuKishimoto, andMitsunoriSakatani 3 1 1 2 3 ClinicalResearchCenter,NationalHospitalOrganizationKinki-ChuoChestMedicalCenter,Osaka591-8555,Japan ChugaiPharmaceuticalCo.,Ltd.,ProductResearchDepartment,Shizuoka412-8513,Japan LaboratoryofImmuneRegulation,GraduateSchoolofFrontierBiosciences,OsakaUniversity,Osaka565-0871,Japan CorrespondenceshouldbeaddressedtoMasajiOkada,okm@kch.hosp.go.jp Received15October2010;Revised24December2010;Accepted28January2011 AcademicEditor:HiroshiNakajima Copyright?2011MasajiOkadaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Objective. Ouraimwastoinvestigate thee?ects ofIL-6 blockadeontheprogressionof Mycobacterium tuberculosis (TB) and comparethemwith thoseofTNF-α blockadein mice. Methods.Micewere intravenouslyinfected with TB andinjected with antibodies.Survivalwasmonitoredandhistologicalandimmunologicalstudieswerecarriedout.Results.Allanti-IL-6RAb-treated miceand8of10controlmicesurviveduntilsacri?ced224daysafterTBchallenge,whereasanti-TNF-αAb-treatedmicealldied between120and181days.Anti-IL-6RAb-treatedmiceexhibitednosigni?cantdi?erencesinTBCFUinorgans,includingthe lungs,andnodeteriorationinhistopathologycomparedtocontrolmiceat4weeks.Incontrast,anti-TNF-αAb-treated mice exhibitedincreasedTBCFUandgreaterprogressionofhistopathological?ndingsinorgansthancontrolmice.Spleencellsfrom anti-TNF-αAb-treatedmicehaddecreasedantigen-speci?cresponseinIFN-γreleaseandproliferationassays.Theresultsin