Anti-inflammatory and immunomodulating effects of clarithromycin in patients with cystic fibrosis lung disease英文文献资料.docVIP

ResearchCommunication MediatorsofInflammation,13(2),111á / 117(April2004) BACKGROUND and aim: Macrolide antibiotics widely used in the treatment of suppurative lung are Anti-in?ammatoryand diseases including cystic fibrosis (CF), the most immunomodulatingeffectsof common inherited fatal disease in the Caucasian population. This condition is characterized by sec- ondary Pseudomonas infection resulting in neutro- phil infiltration within the airways. The aim of the study was to investigate the evolution of inflamma- tory process in CF patients receiving long-term clarithromycininpatientswith cystic?brosislungdisease Alexander L. PukhalskyCA,Galina V. Shmarina, clarithromycintherapy. Methods: Twenty-seven CF patients (mean age, 12 Nikolai I. Kapranov,Svetlana N. Kokarovtseva, years)wereenrolledintothestudy.Besidethebasic therapy the patients were treated with clarithromy- cin at a dose of 250 mg every other day orally. All patients were routinely examined every 3 months. Blood and sputum were collected before clarithro- Daria PukhalskayaandNatalia J. Kashirskaja ResearchCentreforMedicalGenetics,1 mycintreatmentandthenagain3,6and12months MoskvorechieStreet,Moscow,115478,Russia afterthedrugprescription. Cytokineconcentrations (tumornecrosisfactor-a,interleukin-8,interleukin-4, interferon-g)inthesputumandplasmawereassayed. Peripheral blood lymphocyte response to phytohe- CACorrespondingauthor Tel: Fax: / 70951118568 70953240702 magglutininwasalsoevaluated. Results: Clarithromycin treatment resulted in a marked reduction of the cytokine levels both in the sputumandplasmaspecimens.Atthesametime,the / E-mail:osugariver@medgen.ru interferon-g/interleukin-4 ratio has been signifi- cantly elevated. In addition, a sustained increase of peripheral blood lymphocyte response to phytohe- magglutinin was demonstrated. These changes were associatedwithasignificantimprovementofthelung function. Conclusions: The beneficial effect of the prolonged treatment of CF patie