Analysis of Seizure EEG in Kindled Epileptic Rats英文文献资料.docVIP

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Analysis of Seizure EEG in Kindled Epileptic Rats英文文献资料.doc

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Analysis of Seizure EEG in Kindled Epileptic Rats英文文献资料

ComputationalandMathematicalMethodsinMedicine, Vol.8,No.4,December2007,225–234 AnalysisofseizureEEGinkindledepilepticrats A.K.SEN?*,M.J.KUBEK?andH.E.SHANNON{ ?DepartmentofMathematicalSciences,IndianaUniversity,Indianapolis,IN46202,USA ?DepartmentofAnatomyandCellBiology,IndianaUniversitySchoolofMedicine,Indianapolis,IN46202,USA {DivisionofCNSResearch,EliLillyandCompany,LillyCorporateCenter,Indianapolis,IN46285,USA (Received11August2006;revised16May2007;in?nalform20June2007) Using wavelet analysis we have detected the presence of chirps in seizure EEG signals recordedfromkindledepilepticrats.Seizureswereinducedbyelectricalstimulationofthe amygdalaandtheEEGsignalsrecordedfromtheamygdalawereanalyzedusingacontinuous wavelettransform.Atime–frequencyrepresentationofthewaveletpowerspectrumrevealed thatduringseizuretheEEGsignalischaracterizedbyachirp-likewaveformwhosefrequency changes with time from the onset of seizure to its completion. Similar chirp-like time– frequencypro?leshavebeenobservedinnewbornandadultpatientsundergoingepileptic seizures. The global wavelet spectrum depicting the variation of power with frequency showed two dominant frequencies with the largest amounts of power during seizure. Our resultsindicatethatakindlingparadigminratscanbeusedasananimalmodelofhuman temporallobeepilepsytodetectseizuresbyidentifyingchirp-liketime–frequencyvariations intheEEGsignal. Keywords: Seizure;EEG;Chirp;Kindling;Waveletanalysis 1. Introduction Epilepsyisaneurologicaldisorderthataffectsmorethan1%ofpeopleworldwide.Temporal lobeepilepsy(TLE)isthemostcommontypeofepilepsyinhumans.Manyoftheseizures that occur in patients with TLE are classi?ed as complex partial seizures because they originatefromandarecon?nedwithinthetemporallobe.However,innearly60%ofthese patients, the seizures spread from the temporal lobe to other brain regions—a process referredtoassecondarygeneralization.ManyTLEpatientshaveahistoryofbraininjury suchasfebrileseizuresortrauma.Afterrecoveringfromtheinitialp