Anti-inflammatory cytokines in asthma and allergy interleukin-10, interleukin-12, interferon-γ英文文献资料.docVIP

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Anti-inflammatory cytokines in asthma and allergy interleukin-10, interleukin-12, interferon-γ英文文献资料.doc

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Anti-inflammatory cytokines in asthma and allergy interleukin-10, interleukin-12, interferon-γ英文文献资料

Review Mediators of Inflammation, 10, 51–59 (2001) I T-helper type 2 (T of cytokines from T-helper type 1(T NTERLEUKIN-10(IL-10)isacytokinederivedfromCD4 + Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-g ) cells identified as a suppressor H2 H1) cells. Inter- leukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates TH1 cell differentiation, while suppressing the expansion of TH2 cell clones. Interferon-g (IFN-g) is a product of T differentiation. These cytokines have been implicated in the pathogenesis of asthma and allergies. In this cells and exerts inhibitory effects on TH2 cell CA Fan Chung H1 context, IL-12 and IFN-g production in asthma have National Heart Lung Institute, Imperial College School of Medicine, London SW3 6LY, UK been found to be decreased, and this may reduce their capacity to inhibit IgE synthesis and allergic inflam- mation. IL-10 is a potent inhibitor of monocyte/ macrophage function, suppressing the production of many pro-inflammatory cytokines. A relative under- production of IL-10 from alveolar macrophages of atopic asthmatics has been reported. Therapeutic CA Corresponding Author Tel: +44 (0)207 352 8121 ext. 3052/8 Fax: +44 (0)207 351 8126 E-mail: f.chung@ic.ac.uk modulation of T H1 /T imbalance in asthma and H2 allergy by mycobacterial vaccine, specific immuno- therapy and cytolineDguanosine dinucleotide motif may lead to increases in IL-12 and IFN-g production. Stimulation of IL-10 production by antigen-specific T-cells during immunotherapy may lead to anergy through inhibition of CD28-costimulatory molecule signalling by IL-10s anti-inflammatory effect on baso- phils, mast cells and eosinophils. Key words: Interleukin-10, Interleukin-12, interferon-g, T-helper 1 and 2 cells, Asthma, Allergy Introduction tion of the TH2 phenotype, isotype-switching from IgG1 to IgE synthesis, eosinophil mobilisation, matura- The chronic airway i