Anti-Interleukin-1 Agents in Adult Onset Stills Disease英文文献资料.docVIP

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Anti-Interleukin-1 Agents in Adult Onset Stills Disease英文文献资料.doc

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Anti-Interleukin-1 Agents in Adult Onset Stills Disease英文文献资料

HindawiPublishingCorporation InternationalJournalofIn?ammation Volume2012,ArticleID317820,6pages doi:10.1155/2012/317820 ReviewArticle Anti-Interleukin-1AgentsinAdultOnsetStill’sDisease CeciliaGiampietro 1andBrunoFautrel 2,3 1 2 3 DepartmentofInternalMedicine,UniversityofL’Aquila,L’Aquila,Italy SchoolofMedicine,UniversityParis6-PierreetMarieCurie,75013Paris,France DepartmentofRheumatology,AP-HP,Piti′e-Salp?etri`ereUniversityHospital,75013Paris,France CorrespondenceshouldbeaddressedtoCeciliaGiampietro,cecilia.giampietro@ Received9January2012;Accepted7February2012 AcademicEditor:PetrosEfthimiou Copyright?2012C.GiampietroandB.Fautrel. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Interleukin 1β (IL-1β) is emerging as a master mediator of adult onset Still’s disease (AOSD) pathogenesis. This pleiotropic cytokine,whoseexpressionisunderthecontrolofthein?ammasomepathway,hasawidetype ofe?ects.Asakeymediator ofinnateimmunityisapotentpyrogenandfacilitatesneutrophilicproliferationanddiapedesisintothein?amedtissues,which arekeyAOSDmanifestations.Thestudyofproin?ammatorycytokinespro?lesinseraandpathologicaltissuesofAOSDpatients has shown elevated levels of IL-1β, these levels being highly correlated with disease activity and severity. These experimental evidencesandtheanalogywithotherautoin?ammatorydiseasesthatsharewithAOSDclinicalandbiologicalcharacteristicshave suggestedtheblockadeofIL-1βasapossiblenewtherapeuticoptionfortheAOSD,especiallyinconventionaltherapyresistant cases.Anakinra,the?rstanti-IL-1agentputonthemarket,hasdemonstratedcapabletoinducearapidresponsesustainedover time,especiallyinsystemicforms,whereanti-TNFαfailedtocontrolsymptoms.Whileagrowingnumberofevidencessupports theutilisationofanakinrainAOSD,anewgenerationofanti-IL1βantagonistsisdeveloping.Canakinumabandrilonacept,thanks totheirhighera?nityandl