Anti-oxidant activity and cytotoxicity of ethanolic extracts from rhizome of Musa acuminata英文文献资料.docVIP

Vol.3, No.4, 291-294 (2011) Natural Science /10.4236/ns.2011.34037 Anti-oxidant activity and cytotoxicity of ethanolic extracts from rhizome of Musa acuminata Kps Adinarayana *, Ajay P. Babu 1 2 1 2 Department of Anatomy, Andhra Medical College, Visakhapatnam, India; *Corresponding Author: kpsanarayana@ Bio-Lab, Research Gateway for Biosciences, Visakhapatnam, India; dr.ajay@ Received 21 January 2011; revised 20 February 2011; accepted 10 March 2011. ABSTRACT have shown to protect against oxidative stress [4]. Com- pounds such as gallates, have strong antioxidant activity, while others such as the mono-phenols are weak anti- oxidants. Phenolic compounds, in particular, which are widely distributed in many fruits, vegetables and me- dicinal plants accounted for their antioxidant capacity of many plants [5]. In the present study, antioxidant activities of rhizome of Musa acuminata were investigated. Free radical scavenging assay (DPPH) and re- ducing power of the ethanolic extract of banana rhizome resulted in potential antioxidant activi- ties. A relatively high percentage of antioxidant activity by DPPH assay (81.41% at 200 μg/ml) which was comparable to that of the standard, ascorbic acid at 100 μg/ml was observed. With the gallic acid as standard the extract showed a relatively low reductive potential, however, when tested for cytotoxicity at the highest concentra- tion of the tested dose (256 μg/ml), the maxi- mum rate of inhibition observed was 50.32%. The present work indicates that the ethanolic extract of Musa acuminata exhibits significant antiproliferative and antioxidant activities. Antioxidants play major role in neutralizing the ef- fects of free radicals and are known to be effective in preventing the free radical formation by scavenging or promotion of their decomposition [6]. Free radicals pre- sent in the biological syst