Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease英文文献资料.docVIP

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Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease英文文献资料.doc

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Anti-Inflammatory Effects of Interleukin-19 in Vascular Disease英文文献资料

HindawiPublishingCorporation InternationalJournalofIn?ammation Volume2012,ArticleID253583,10pages doi:10.1155/2012/253583 ReviewArticle Anti-In?ammatoryEffectsofInterleukin-19inVascularDisease RossN.EnglandandMichaelV.Autieri DepartmentofPhysiology,IndependenceBlueCrossCardiovascularResearchCenter,TempleUniversitySchoolofMedicine, Philadelphia,PA19140,USA CorrespondenceshouldbeaddressedtoMichaelV.Autieri,mautieri@ Received21March2012;Accepted10May2012 AcademicEditor:IchiroManabe Copyright?2012R.N.EnglandandM.V.Autieri. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkis properlycited. Despiteaggressivedietarymodi?cation,lipid-loweringmedications,andotherinterventionalmedicaltherapy,vasculardisease continues to be a leading cause of mortality in the western world. It is a signi?cant medical and socioeconomic problem contributingtomortalityofmultiplediseasesincludingmyocardialinfarction,stroke,renalfailure,andperipheralvasculardisease. Morbidity and mortality of vascular disease are expected to worsen with the increasing number of patients with comorbid conditionssuchasobesity,metabolicsyndrome,anddiabetesmellitustype2.Vasculardiseasessuchasatherosclerosis,restenosis, andallograftvasculopathyarerecognizedtobedrivenbyin?ammation,andassuch,cytokineswhichmediatein?ammationnot onlyrepresentimportanttargetsofrationaltherapy,butalsocanbeconsideredaspossibletherapeuticmodalitiesthemselves.In thispaper,wewillexaminetheroleofin?ammatorycytokinesandlymphocyteTh1/Th2polarityinvascularin?ammation,with afocusonatheroscleroticvasculardisease.WewillthenintroducearecentlydescribedTh2interleukin,interleukin-19(IL-19),as a previously unrecognized mediator of vascular in?ammatory disorders. We will review our current understanding of this interleukininhealthanddiseaseandpresentthepossibilitythatIL-19couldrepresentapotentialtherapeutictocombatvascular in?a