Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice英文文献资料.docVIP

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Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice英文文献资料.doc

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Anti-Inflammatory Effects of Adrenomedullin on Acute Lung Injury Induced by Carrageenan in Mice英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2012,ArticleID717851,13pages doi:10.1155/2012/717851 ResearchArticle Anti-In?ammatoryEffectsofAdrenomedullinonAcuteLung InjuryInducedbyCarrageenaninMice TaleroElena, 1 DiPaolaRosanna, 2 MazzonEmanuela,2,3EmanuelaEsposito,2 MotilvaVirginia, 1 andCuzzocreaSalvatore 2,4 1 2 DepartmentofPharmacology,SchoolofPharmacy,UniversityofSeville,41012Seville,Spain DepartmentofClinicalandExperimentalMedicineandPharmacology,SchoolofMedicine,UniversityofMessina, TorreBiologica,PoliclinicoUniversitario,ViaC.Valeria,Gazzi,98100Messina,Italy IRCCSCentroNeurolesi“Bonino-Pulejo”,S.S.113ViaPalermo,CTRCasazza,98100Messina,Italy UniversityofManchester,ManchesterM139PL,UK 3 4 CorrespondenceshouldbeaddressedtoCuzzocreaSalvatore,salvatore.cuzzocrea@unime.it Received30November2011;Revised8March2012;Accepted19March2012 AcademicEditor:AlexKleinjan Copyright?2012TaleroElenaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Adrenomedullin(AM)isa52aminoacidpeptidethathasshownpredominantanti-in?ammatoryactivities.Inthepresentstudy, weevaluatedthepossibletherapeutice?ectofthispeptideinanexperimentalmodelofacutein?ammation,thecarrageenan- (CAR-) induced pleurisy. Pleurisy was induced by injection of CAR into the pleural cavity of mice. AM (200ng/kg) was administeredbyintraperitonealroute1hafterCAR,andtheanimalsweresacri?ced4hafterthat.AMtreatmentattenuated therecruitmentofleucocytesinthelungtissueandthegenerationand/ortheexpressionoftheproin?ammatorycytokinesas well as the expression of the intercellular cell adhesion molecules. Moreover, AM inhibited the induction of inducible nitric oxidesynthase(iNOS),therebyabatingthegenerationofnitricoxide(NO)andpreventedtheoxidativeandnitroxidativelung tissueinjury,asshownbythereductionofnitrotyrosine,malondialdehyde(MDA),andpoly(ADP-ribose)polymerase(PARP) levels.F