Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice英文文献资料.docVIP

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Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice英文文献资料.doc

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Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2011,ArticleID912925,11pages doi:10.1155/2011/912925 ResearchArticle Anti-in?ammatoryandAntinociceptiveActivityof OuabaininMice DanielleIngridBezerradeVasconcelos,1,2JacquelineAlvesLeite, M′arciaReginaPiuvezam,1,2MariaRaquelVitorinodeLima, LianaCl′ebiaLimadeMorais, VivianMaryRumjanek, andSandraRodrigues-Mascarenhas 1,2 1 1 LucianaTelesCarneiro, 1 1 3 1 2 3 Laborat′oriodeTecnologiaFarmac?eutica,DepartamentodeFisiologiaePatologia,CentrodeCi?enciasdaSa′ude, UniversidadeFederaldaPara′?ba,Jo?aoPessoa58059-900,Brazil DepartamentodeBiologiaMolecular,CentrodeCi?enciasExatasedaNatureza,UniversidadeFederaldaPara′?ba, Jo?aoPessoa58059-900,Brazil InstitutodeBioqu′?micaM′edica,CentrodeCi?enciasdaSa′ude,UniversidadeFederaldoRiodeJaneiro, RiodeJaneiro21941-902,Brazil CorrespondenceshouldbeaddressedtoSandraRodrigues-Mascarenhas,sandramascarenhas@ltf.ufpb.br Received23November2010;Revised17February2011;Accepted26March2011 AcademicEditor:MuzamilAhmad Copyright?2011DanielleIngridBezerradeVasconcelosetal. This is an open access article distributed under the Creative CommonsAttribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the originalworkisproperlycited. Ouabain,aninhibitoroftheNa /K -ATPasepump,wasidenti?edasanendogenoussubstanceofhumanplasma.Ouabainhas + + beenstudiedforitsabilitytointerferewithvariousregulatorymechanisms.Despitethestudiesportrayingtheabilityofouabain tomodulatetheimmuneresponse,littleisknownaboutthee?ectofthissubstanceonthein?ammatoryprocess.Theaimofthis workwastostudythee?ectstriggeredbyouabainonin?ammationandnociceptivemodels.Ouabainproducedareductionin themousepawedemainducedbycarrageenan,compound48/80andzymosan.Thisanti-in?ammatorypotentialmightberelated totheinhibitionofprostaglandinE2,bradykinin,andmast-celldegranulationbutnottohistamine.Ouabainalsomodulated the in?ammation induced by concanavalin A by inhibiting ce