Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals英文文献资料.docVIP

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Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals英文文献资料.doc

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Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals英文文献资料

HindawiPublishingCorporation MediatorsofIn?ammation Volume2012,ArticleID243158,10pages doi:10.1155/2012/243158 ClinicalStudy Anti-ApolipoproteinA-1IgGLevelsPredictCoronaryArtery Calci?cationinObesebutOtherwiseHealthyIndividuals AlessandraQuercioli, OsmanRatib, 1FabrizioMontecucco,1,2KatiaGalan,1 3 PascaleRoux-Lombard, 4 4 1 ThomasH.Schindler, andNicolasVuilleumier SabrinaPagano, Franc?oisMach, 4 1 1 DivisionofCardiology,DepartmentofMedicalSpecialties,GenevaUniversityHospitalsandUniversityofGeneva, 4RueGabriellePerret-Gentil,1211Geneva,Switzerland 2 3 4 FirstClinicofInternalMedicine,DepartmentofInternalMedicine,UniversityofGenoa,6VialeBenedettoXV,16100Genoa,Italy DivisionofNuclearMedicine,GenevaUniversityHospitals,4RueGabriellePerret-Gentil,1211Geneva,Switzerland DivisionofLaboratoryMedicine,DepartmentofGeneticsandLaboratoryMedicine,GenevaUniversityHospitals, 4RueGabriellePerret-Gentil,1211Geneva,Switzerland CorrespondenceshouldbeaddressedtoAlessandraQuercioli,alessandra.quercioli@hcuge.ch Received3August2012;Revised10October2012;Accepted11October2012 AcademicEditor:EricF.Morand Copyright?2012AlessandraQuerciolietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calci?cation (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease. 48 nonobeseand43obesesubjectswereincluded.CACscorewasmeasuredbythoraxscannerandde?nedbyanAgatstonscore 0.Coronaryendothelialdysfunctionwasdeterminedbymeasuringmyocardialblood?owresponsestocoldpressortest(CPT) onPET/CT.Serumanti-apoA-1IgGlevelsweremeasuredbyELISA.Prevalenceofcoronarycalci?cationwassimilarbetweenthe twostudygroups,buttheprevalenceofcoronaryendoth