Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome英文文献资料.docVIP

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Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome英文文献资料.doc

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Antibodies Against β2-Glycoprotein I Complexed With an Oxidised Lipoprotein Relate to Intima Thickening of Carotid Arteries in Primary Antiphospholipid Syndrome英文文献资料

ClinicalDevelopmentalImmunology,March2006;13(1):1–9 Antibodiesagainstb2-glycoproteinIcomplexedwithanoxidised lipoproteinrelatetointimathickeningofcarotidarteriesinprimary antiphospholipidsyndrome P.R.J.AMES1,J.DELGADOALVES2,L.R.LOPEZ3,F.GENTILE4,A.MARGARITA5, L.PIZZELLA6,J.BATUCA2,G.SCENNA5,V.BRANCACCIO5,E.MATSUURA7 1AcademicDepartmentofRheumatology,LeedsGeneralIn?rmary,Leeds,UK, 2DepartmentofPharmacology,Facultyof MedicalSciences,NewUniversityofLisbon,Lisbon,Portugal, 3Corgenix,Inc,Westminster,Colorado,USA, 4Departmentof HealthSciences(SpeS),MoliseUniversity,Campobasso,Italy,5AngiologyandCoagulationUnitsCardarelliHospital,Naples, Italy, 6DepartmentofAnimal,AgriculturalEnvironmentalSciences(SAVA),MoliseUniversity,Campobasso,Italy,and 7DepartmentofCellChemistry,GraduateSchoolofMedicine,DentistryandPharmaceuticalSciences,OkayamaUniversity, Okayama,Japan Abstract To explore whether antibodies against b2-glycoprotein I (b2GPI) complexed to 7-ketocholesteryl-9-carboxynonanoate (oxLig-1) and to oxidised low-density lipoproteins (oxLDL) relate to paraoxonase activity (PONa) and/or intima media thickness(IMT)ofcarotidarteriesinprimaryantiphospholipidsyndrome(PAPS).Asmanyas29thromboticpatientswith PAPS, 10 subjects with idiopathic antiphospholipid antibodies (aPL) without thrombosis, 17 thrombotic patients with inheritedthrombophiliaand23healthycontrolswereinvestigated.Thefollowingweremeasuredinallparticipants:b2GPI– oxLDL complexes, IgG anti-b2GPI–oxLig-1, IgG anti-b2GPI–oxLDL antibodies (ELISA), PONa, (para-nitrophenol method),IMTofcommoncarotid(CC)artery,carotidbifurcation(B),internalcarotid(IC)byhighresolutionsonography. b2GPI–oxLDL complex was highest in the control group (p,0.01), whereas, IgG anti-b2GPI–oxLig1 and IgG anti- b2GPI–oxLDLwerehighestinPAPS(p,0.0001).Inhealthycontrols,b2GPI–oxLDLcomplexespositivelycorrelatedto IMToftheIC(p?0.007)andnegativelytoPONaaftercorrectionforage(p,0.03).PONainverselycorrelatedwithage (p?0.008).InPAPS,IgGanti-b GPI–o