Antimicrobial Activity of Terminalia catappa Extracts Against Some Pathogenic Microbial Strains英文文献资料.docVIP

Pharmacology Pharmacy, 2011, 2, 299-305 299 doi:10.4236/pp.2011.24038 Published Online October 2011 (http://www.SciRP.org/journal/pp) Antimicrobial Activity of Terminalia catappa Extracts against Some Pathogenic Microbial Strains Abul Manzur , Arifuddin Raju , Shahedur Rahman 1* 1 2 1 Department of Microbiology, North South University, Dhaka, Bangladesh; Islamic University, Kushtia, Bangladesh. 2 Department of Biotechnology and Genetic Engineering, Email: abulmanzur1975@ * Received September 4 , 2011; revised September 27 , 2011; accepted October 20 , 2011. th th th ABSTRACT The methanol, acetone and N,N-dimethylformamide extracts of Terminalia catappa L. leaf were evaluated for antibac- terial and antifungal activity. Piperacillin and gentamicin were used as standards for antibacterial assay, while nystatin and flucanazole were used as standards for antifungal assay. 91 clinically important strains were used for the study which were both clinical isolates as well as identified strains. The antimicrobial activity of all the extracts was deter- mined by agar disc diffusion method. The antibacterial activity was more pronounced against bacteria than fungal strains. The Gram positive bacteria were more susceptible than Gram negative bacteria. The methanol extract showed best antibacterial activity. T. catappa leaf extracts showed better antibacterial activity than commercially used antibi- otics. Keywords: Terminalia catappa, Antibacterial Activity, Antifungal Activity, Clinical Strains, Organic Solvents 1. Introduction shade, and salt-tolerant street tree, but the leaves provide food for the Tasar silkworm, and the seeds are edible like almonds with similar oils. On the Malay peninsular and throu