Are mean platelet volume and splenomegaly subclinical inflammatory marker in children with familial mediterranean fever英文文献资料.docVIP

Vol.2, No.7, 692-695 (2010) Health doi:10.4236/health.2010.27105 Are mean platelet volume and splenomegaly subclinical inflammatory marker in children with familial mediterranean fever? Ismail Dursun *, Faysal Gok , Oguzhan Babacan , Erkan Sar? , Onur Sakall?oglu , 1 1 2 2 1 1 2 Suleyman Kalman , Ibrahim Gokce 1 * 2 Department of Pediatric Nephrology and Rheumatology, Gülhane Military Medical Academy, School of Medicine, Ankara, Turkey; Corresponding Author: drdursun@ Department of Pediatrics, Gülhane Military Medical Academy, School of Medicine, Ankara, Turkey; faysalgok@, gokcemd@ Received 6 February 2010; revised 2 Mrach 2010; accepted 5 March 2010. ABSTRACT higher than control in attack free period of FMF (3). IL-6 has been shown to promote megakaryocyte matura- tion in the absence of other growth factors. It possibly stimulates megakaryocyte proliferation. Administration of IL-6 has been shown to result in a significant increase in the platelet count [5]. Also it is a cytokine that can induce the formation of SAA and C-reactive protein (CRP) [6-8]. Erythrocyte sedimentation rate, CRP and SAA correlate closely with clinical disease activity in FMF patients [4]. The present study aimed to investigate the cor- relation of MPV and splenomegaly as inflamma- tion activity of FMF patients at the attacks free period. We retrospectively reviewed the medical records of 43 patients with FMF. This study was performed at the attack free period as clinical and laboratory. For this study, patients were divided into two groups. Patients with spleno- megaly is called group 1 (n = 12) and patients with no splenomegaly is called group 2 (n = 31). Groups were compared respect to age, gender, platelet c