Antioxidant Vitamins in the Prevention of Atrial Fibrillation What Is the Evidence英文文献资料.docVIP

SAGE-HindawiAccesstoResearch CardiologyResearchandPractice Volume2011,ArticleID164078,8pages doi:10.4061/2011/164078 ReviewArticle AntioxidantVitaminsinthePreventionofAtrialFibrillation: WhatIstheEvidence? SoniaRasoli, 1 NicholaosKakouros, LeanneHarling, PhilemonGukop, ManishSoni, 2 3 1 1 andAntoniosKourliouros 4 ThanosAthanasiou, 3 1 2 3 4 DepartmentofCardiothoracicSurgery,StGeorge’sHospital,LondonSW170QT,UK DepartmentofCardiology,JohnsHopkinsHospital,Baltimore,MD21209,USA DepartmentofCardiothoracicSurgery,ImperialCollegeHealthcare,LondonW120HS,UK DepartmentofCardiacSurgery,StThomas’Hospital,LondonSE17EH,UK CorrespondenceshouldbeaddressedtoAntoniosKourliouros,akou@.uk Received23December2010;Accepted19May2011 AcademicEditor:AlawiA.Alsheikh-Ali Copyright?2011SoniaRasolietal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Atrial?brillation(AF)isthemostcommonsustainedarrhythmiathatisassociatedwithsigni?cantmorbidityandmortality. Current available therapies remain inadequate in symptom control and secondary prevention and are often associated with signi?cantsidee?ects.ThemechanismsunderlyingthepathogenesisofAFarepoorlyunderstood,althoughelectrophysiological remodeling has been described as an important initiating step. Recently, increasing evidence implicates oxidative stress and in?ammationinthepathogenesisofAF.WesearchedtheliteratureforevidencetosupporttheuseofantioxidantvitaminsC and E in the prevention of AF. These vitamins, through their reactive-oxygen-species- (ROS-) scavenging e?ect, have shown aroleinAFpreventioninbothanimalandsmallclinicalstudies.Theavailableevidence,however,iscurrentlyinsu?cientto supportrecommendationsfortheiruseinthewiderpatientpopulation.Larger-scaleclinicalstudiesarerequiredtocon?rmthese preliminaryresults.Researchisalsorequiredtofurthertheunderstandin