Antimicrobial activity of the autochthonous compound Enoxil英文文献资料.docVIP

J. Biomedical Science and Engineering, 2010, 3, 758-762 JBiSE doi:10.4236/jbise.2010.38101 Published Online August 2010 (http://www.SciRP.org/journal/jbise/). Antimicrobial activity of the autochthonous compound Enoxil Lucian Lupa?cu , Valeriu Rudic , Viorica Cotos , Tudor Lupa?cu 1 1,2 3 4 1 2 3 4 Institute of Microbiology and Biotechnology of the ASM, Chi?in?u, Moldavia; Academy of Sciences of Moldova (ASM), Chi?in?u, Moldavia; Hospital of Contagious Diseases “T. Ciorba”, Chi?in?u, Moldavia; Institute of Chemistry of the ASM, Chi?in?u, Moldavia. Email: lucian1978@mail.ru Received 24 February 2010; revised 18 March 2010; accepted 31 March 2010. ABSTRACT these compounds [12,13]. A permanent and, often, abu- sive treatment with antibiotics had as a result the selec- tion of new virulences, aggressive and severe, with a high genetic resistance potential. This situation directs the specialists in the field towards the elaboration of antimicrobial compounds on the basis of novel action mechanisms [14]. Albeit the use of tannin extracts from plants for the treatment of various derma and plagues infections has been known for a long time, these don’t exhibit the expected effect for many microorganisms [15-17]. At the moment, the number of efficient medici- nal compounds, elaborated on the basis of tannin com- pounds is quite low, mostly due to the insolubility of many of them in aqueous or alcoholic solutions. The capacity of phenolic (tannin) extracts to disinfect and rapidly treat wounds is based on two fundamental phe- nomena—antimicrobial and antioxidant activities, de- termined by a series of mechanisms: capturing of iron ions from the substrate, thus depriving microorganisms of compounds necessary for their physiological activity; their binding to