Antipsychotic and Anticholinergic Drug Prescribing Pattern in Psychiatry Extent of Evidence-Based Practice in Bahrain英文文献资料.docVIP

Pharmacology Pharmacy, 2012, 3, 409-416 1 /10.4236/pp.2012.34055 Published Online October 2012 (http://www.SciRP.org/journal/pp) Antipsychotic and Anticholinergic Drug Prescribing Pattern in Psychiatry: Extent of Evidence-Based Practice in Bahrain* Khalid A. J. Al Khaja , Mohammed K. Al-Haddad , Reginald P. Sequeira , Adel R. Al-Offi 1# 2 1 3 1 Department of Pharmacology Therapeutics, Arabian Gulf University, Manama, Bahrain; Department of Psychiatry, Arabian Gulf 2 University, Manama, Bahrain; Psychiatric Hospital, Ministry of Health, Manama, Bahrain. # Email: khlidj@.bh 3 Received May 7 , 2012; revised June 13 , 2012; accepted July 12 , 2012 th th th ABSTRACT The aim of this study is to determine the antipsychotic prescribing pattern and the prevalence of concurrent anticho- linergic prescribing in a psychiatric referral hospital. A retrospective audit of prescriptions issued for outpatients was carried out at the Psychiatric Hospital, the only facility that provides psychiatric services for both inpatients and outpa- tients in the Kingdom of Bahrain. Antipsychotic monotherapy was prescribed for 89.2% patients, whereas polytherapy with two- and three-drugs in 10.4% and 0.4%, respectively. Atypical antipsychotics were prescribed more often (67.7%) than typical antipsychotics. Risperidone and haloperidol were the most frequently prescribed antipsychotics. Long-act- ing risperidone injection was the only depot preparation prescribed. The mean antipsychotic dose expressed as chlor- promazine equivalent (CPZeq; mg/day) was 242 (220 for monotherapy and 414 for polytherapy). The prevalence of high dose antipsychotic (mean CPZeq 1000 mg/day)