Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART英文文献资料.docVIP

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Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART英文文献资料.doc

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Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART英文文献资料

HindawiPublishingCorporation ClinicalandDevelopmentalImmunology Volume2011,ArticleID758350,9pages doi:10.1155/2011/758350 ResearchArticle AntiretroviralTreatment-AssociatedTuberculosisin aProspectiveCohortofHIV-InfectedPatientsStartingART WilliamWorodria,1,2,3,4MargueriteMassinga-Loembe, AndrewKambugu, HarrietMayanja-Kizza,1,2,3JaneNamaganda, 3 YukariC.Manabe,2,3,6LucKestens,4,5andRobertColebunders 4,5 5 3 1 2 3 4 5 6 DepartmentofMedicine,MulagoHospital,CollegeofHealthSciences,MakerereUniversity,P.O.Box7051,Kampala,Uganda InfectiousDiseasesNetworkforTreatmentandResearchinAfrica(INTERACT),MakerereUniversity,Kampala,Uganda InfectiousDiseaseInstitute,CollegeofHealthSciences,MakerereUniversity,Kampala,Uganda UniversityofAntwerp,2020Antwerpen,Belgium InstituteofTropicalMedicine,2000Antwerpen,Belgium DivisionofInfectiousDiseases,DepartmentofMedicine,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,MD,USA CorrespondenceshouldbeaddressedtoWilliamWorodria,worodria@ Received7July2010;Revised15September2010;Accepted10October2010 AcademicEditor:GraemeMeintjes Copyright?2011WilliamWorodriaetal.This isanopen access article distributed underthe Creative CommonsAttribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmaskingofsubclinicaldisease.Thesubsetofpatientsthatarediagnosedwithtuberculosis(TB)diseasewhileonARThave been classi?edasART-associatedTB.Fewstudieshavereported theincidenceofART-associatedTBandunmaskingTB-IRIS accordingtotheInternationalNetworkfortheStudyofHIV-AssociatedIRIS(INSHI)consensusde?nition.Todeterminethe incidenceandpredictorsofART-associatedTB,wescreened219patientscommencingARTattheInfectiousDiseasesClinicin Kampala,UgandaforTBbysymptoms,sputummicroscopy,andchestX-raysandfollowedthemforoneyear.Fourteen(6.4%) patientswerediagnosedwithTBduring