Arterial mechanical properties after replacement or reconstruction of the aortic root英文文献资料.docVIP

World Journal of Cardiovascular Diseases, 2012, 2, 8-13 WJCD /10.4236/wjcd.2012.21002 Published Online January 2012 (http://www.SciRP.org/journal/wjcd/) Arterial mechanical properties after replacement or reconstruction of the aortic root Kai Mortensen 1* , Muhammet Aydin , Jürgen Berger 1* , Alexander M. J. Bernhardt 1 , Verena Appenzeller 1 , Peter N. Robinson 2 1 , Herman Reichenspurner , Yskert von Kodolitsch 1 1 1 2 Centre of Cardiology and Cardiovascular Surgery at the University Hospital Eppendorf, Hamburg, Germany Institute for Medical and Human Genetics, Charité Universit?tsmedizin, Berlin, Germany Email: kodolitsch@uke.de Received 4 October 2011; revised 14 December 2011; accepted 28 December 2011 ABSTRACT aortic root with a composite valve grafting operation according to Bentall (CVG) has improved life expec- tancy of affected persons significantly. More recent sur- gical approaches have made it possible to preserve the native aortic valve [3]. We wanted to evaluate arterial mechanical properties in Marfan patients without any previous aortic root surgery and in patients after different types of aortic root surgery. Background: Alteration of arterial mechanical prop- erties has adverse effects on cardiovascular disease in Marfan syndrome. Design: We compared central pulse pressure, augmentation index adjusted to a heart rate of 75 beats per minute (AIx@HR75) and pulse wave velocity in 25 Marfan patients who had undergone an aortic valve-sparing reimplantation ope- ration, in 15 Marfan patients after composite valve grafting operation, and in 40 age and sex-matched Marfan patients who had not undergone surgery. Re- sults: Central pulse pressure, AIx@HR75 and pulse wave velocity were similar across all three patient groups. Exclusively AIx@HR75 was higher with con- duit operations than in persons without