Assessing GastroPanel serum markers as a non-invasive method for the diagnosis of atrophic gastritis and Helicobacter pylori infection英文文献资料.docVIP

Open Journal of Gastroenterology, 2012, 2, 113-118 OJGas /10.4236/ojgas.2012.23024 Published Online August 2012 (http://www.SciRP.org/journal/ojgas/) Assessing GastroPanel serum markers as a non-invasive method for the diagnosis of atrophic gastritis and Helicobacter pylori infection Dominique Noah Noah , Marie Claire Okomo Assoumou , Servais Albert Fiacre Eloumou Bagnaka , 1* 2 3 2 5 2,6 Guy Pascal Ngaba 4 , Ivo Ebule Alonge , Lea Paloheimo , Oudou Njoya 1 2 3 4 5 6 Yaounde Central Hospital, Faculty of Medicine and Pharmaceuticals Sciences, University of Douala, Douala, Cameroon Faculty of Medicine and Biomedical Sciences, University of Yaounde, Yaounde, Cameroon Douala General Hospital, Faculty of Medicine and Pharmaceuticals Sciences, University of Douala, Douala, Cameroon District Hospital of Bonassama, Faculty of Medicine and Pharmaceuticals Sciences, University of Douala, Douala, Cameroon Biohit, Helsinki, Finland University Teaching Hospital, Yaounde, Cameroon Email: noahnoahd@yahoo.fr * Received 10 May 2012; revised 11 June 2012; accepted 25 June 2012 ABSTRACT method (81.4%). These results suggest that diagnosis of atrophic gastritis and H. pylori infection obtained with an optional serological method (GastroPanel) is in a strong agreement with the biopsy findings, and thus can be a useful non endoscopic assessment of stomach mucosal atrophy in patients with dyspepsia. Gastric colonization by Helicobacter pylori increases the risk of gastric disorders, including atrophic gas- tritis which can be diagnosed based on levels of serum biomarkers like Gastrin and Pepsinogen. We therefore examined the efficacy of a serological-based method namely Gastr