Autoimmune Thyroid, Celiac and Addison’s Diseases Related to HLA-DQ Types in Young Patients with Type 1 Diabetes in Belgium英文文献资料.docVIP

Open Journal of Endocrine and Metabolic Diseases, 2012, 2, 70-73 /10.4236/ojemd.2012.24011 Published Online November 2012 (http://www.SciRP.org/journal/ojemd) Autoimmune Thyroid, Celiac and Addison’s Diseases Related to HLA-DQ Types in Young Patients with Type 1 Diabetes in Belgium Anissa Messaaoui , Sylvie Tenoutasse , Bart Van der Auwera , Christian Mélot , Harry Dorchy 1 1 2 3 1 1 Diabetology Clinic, University Children’s Hospital Queen Fabiola, Université Libre de Bruxelles, Brussels, Belgium 2 Belgian Diabetes Registry, Brussels, Belgium 3 Statistics Department, Erasme Academic Hospital, Université Libre de Bruxelles, Brussels, Belgium Email: anissa.messaaoui@huderf.be Received August 24, 2012; revised September 25, 2012; accepted October 27, 2012 ABSTRACT Objective: To define the prevalence of auto antibodies (Ab) to different organs in young patients with type 1 diabetes (type 1DM). Methods: Ab to thyroid, celiac and adrenal disease was analyzed in 831 type 1 DM patients. Results: Hundred twenty-three (14.8%) had positive thyroid Ab. The risk of developing thyroid Ab was increased in girls (HR 2.3; 95% CI 1.6 - 3.2, p 0.0001). Thirty-three (3.9%) patients had positive endomysium Ab (3.1% in girls and 3.5% in boys, p = NS). Adrenal Ab was detected in 5 patients. The DQA1*0301-DQB1*0301 haplotype was more prevalent in patients with thyroid Ab (p = 0.0281); DQA1*301-DQB1*302 and DQA1*501-DQB1*201 in patients with endo- mysium Ab (p = 0.0251 and p 0.0001). All patients with adrenal Ab were DQA1*301-DQB1*302 positive. Conclu- sions: Type 1D patients should be screened annually for thyroid autoimmunity and celiac disease. The DQA1*0301-DQB1*0301 haplotype seems to confer susceptibility to thyroid autoim