Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration英文文献资料.docVIP

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Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration英文文献资料.doc

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Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration英文文献资料

HindawiPublishingCorporation InternationalJournalofBiomaterials Volume2011,ArticleID175362,8pages doi:10.1155/2011/175362 ResearchArticle BacterialCellulose-HydroxyapatiteNanocompositesfor BoneRegeneration A.M.M.Gaspar, R.Marchetto, S.J.L.Ribeiro, andY.Messaddeq S.Saska,1,2H.S.Barud,1 3 1 1 1 1 2 3 InstituteofChemistry,UniversityEstadualPaulista—UNESP,CP355,14-801-970Araraquara,SP,Brazil DepartmentofInorganicChemistry,InstituteofChemistry—UNESP,RuaFranciscoDegnis/n,14-800-900Araraquara,SP,Brazil DepartmentofMorphology,DentalSchool,UniversityEstadualPaulista—UNESP,RuaHumait′a,1680, 14-801-903Araraquara,SP,Brazil CorrespondenceshouldbeaddressedtoS.Saska,sybele saska@.br Received28March2011;Revised1June2011;Accepted7July2011 AcademicEditor:TraianV.Chirila Copyright?2011S.Saskaetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. The aim of this study was to develop and to evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC- HA) nanocomposite membranes for bone regeneration. Nanocomposites were prepared from bacterial cellulose membranes sequentiallyincubatedinsolutionsofCaCl2followedbyNa2HPO4.BC-HAmembraneswereevaluatedinnoncriticalbonedefects inrattibiaeat1,4,and16weeks.Thermogravimetricanalysesshowedthattheamountofthemineralphasewas40%–50%of thetotalweight.Spectroscopy,electronicmicroscopy/energydispersiveX-rayanalyses,andX-raydi?ractionshowedformationof HAcrystalsonBCnano?bres.LowcrystallinityHAcrystalspresentedCa/Pamolarratioof1.5(calcium-de?cientHA),similarto physiologicalbone.Fouriertransformedinfraredspectroscopyanalysisshowedbandsassignedtophosphateandcarbonateions. Invivotestsshowednoin?ammatoryreactionafter1week.After4weeks,defectswereobservedtobecompletely?lledinbynew bonetissue.TheBC-HAmembranesweree?ectiveforboneregeneration.