Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel英文文献资料.docVIP

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Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel英文文献资料.doc

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Bevacizumab and Weekly Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer Previously Exposed to Docetaxel英文文献资料

HindawiPublishingCorporation ProstateCancer Volume2011,ArticleID258689,7pages doi:10.1155/2011/258689 ClinicalStudy BevacizumabandWeeklyDocetaxelinPatientswith MetastaticCastrate-ResistantProstateCancerPreviously ExposedtoDocetaxel FilippoFrancini, RaffaeleConca, GiorgioChiriaco`, RobertoPonchietti, 1 AlessandraPascucci, AntonellaLicchetta, GiandomenicoRoviello, SalvatoraTindaraMiano, GiuseppeMarzocca, VinnoSavelli, andRobertoPetrioli 2 EdoardoFrancini, 2 GianlucaBargagli, IgnazioMartellucci, AntonioManganelli, 4 2 2 2 2 2 2 2 3 5 6 2 1 DepartmentofOdontostomatologyandMaxillo-FacialSurgery,UniversityofSiena,PoliclinicoLeScotte, VialeBracci11,53100Siena,Italy 2 3 4 5 6 MedicalOncology,UniversityofSiena,PoliclinicoLeScotte,VialeBracci11,53100Siena,Italy GeneralSurgery,UniversityofSiena,PoliclinicoLeScotte,VialeBracci11,53100Siena,Italy UrologicSurgery,UniversityofSiena,PoliclinicoLeScotte,VialeBracci11,53100Siena,Italy GenitourinaryUnit,UniversityofSiena,PoliclinicoLeScotte,VialeBracci11,53100Siena,Italy DepartmentofSurgery,UniversityofSiena,PoliclinicoLeScotte,VialeBracci11,53100Siena,Italy CorrespondenceshouldbeaddressedtoRobertoPetrioli,r.petrioli@ao-siena.toscana.it Received22March2011;Accepted21June2011 AcademicEditor:RaviA.Madan Copyright?2011FilippoFrancinietal. This is an open access article distributed under the Creative Commons Attribution License,whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperly cited. Background.Theaimofthispaperwastoevaluatetheactivityandtolerabilityofdocetaxel(D)andbevacizumab(Bev)inpatients withmetastaticcastrate-resistantprostatecancer(CRPC)previouslyexposedtoD.Methods.TreatmentconsistedofD30mg/m 2 i.v.forfourconsecutiveweeklyadministrationsfollowedbya2-weekrestinterval,inadditiontoBev5mg/kgi.v.every2weeks. Results.Forty-threepatientswereenrolled:aPSAresponsewasobservedin27patients(62.7%,95%CI:0.41to0.91),anda palliativeresponsewasachievedin31patients(72.1%,95%CI:0.48to1.02).Aftera