Blood-Oxygenation-Level-Dependent-(BOLD-) Based R2′ MRI Study in Monkey Model of Reversible Middle Cerebral Artery Occlusion英文文献资料.docVIP

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Blood-Oxygenation-Level-Dependent-(BOLD-) Based R2′ MRI Study in Monkey Model of Reversible Middle Cerebral Artery Occlusion英文文献资料.doc

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Blood-Oxygenation-Level-Dependent-(BOLD-) Based R2′ MRI Study in Monkey Model of Reversible Middle Cerebral Artery Occlusion英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2011,ArticleID318346,8pages doi:10.1155/2011/318346 ResearchArticle Blood-Oxygenation-Level-Dependent-(BOLD-)Based R2MRIStudyinMonkeyModelofReversibleMiddleCerebral ArteryOcclusion JingZhang,Ying-minChen,andYun-tingZhang DepartmentofRadiology,GeneralHospital,TianjinMedicalUniversity,154AnshanRoadHepingDistrictTianjin300052,China CorrespondenceshouldbeaddressedtoYun-tingZhang,cjr.zhangyunting@ Received10September2010;Revised25November2010;Accepted30December2010 AcademicEditor:AndreaVecchione Copyright?2011JingZhangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense, whichpermitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. Objective.ToinvestigatethevalueofBOLD-basedreversibletransverserelaxationrate(R2 (IP)in a monkeymodel ofreversible middle cerebral artery occlusion(MCAO)andtimeevolutionofrelative R2 infarcted core,IP,andoligemia.Materials andMethods.6monkeyswere usedtomakeMCAObythemicrocatheter method. MRscanswereperformedat0h(1hafterMCAO),1h,3h,6h,12h,24h,and48hafterreperfusion.R2 wascalculatedusing quantitativeT2andT2 maps.Ischemicareawassubdividedintoinfractedcore,IPandoligemia.rR2 wascalculatedrespectively. Results.ReversibleMCAOmodelfor4/6monkeyswasmadesuccessfully.rR2 valuesweresigni?cantlydi?erentateach time point,beinghighestinoligemiafollowedbyIPandinfarctedcore(P .05).Withreperfusiontimeevolution,rR2 ininfarcted coreshowedadecreasedtrend:sharplydecreasedwithin6hoursandmaintainedat0during6–48hours(P.05).rR2 valuesin IPandoligemiashowedsimilarincreasedtrend:sharplyincreasedwithin6hours,maintainedaplateauduring6–24hours,and slightlyincreaseduntil48hours.Conclusion.BOLD-basedR2 MRIcanbeusedtodescribechangesofcerebraloxygenextractin acuteischemicstroke,anditcanprovideadditionalinformationindetectingIP.ThetimeevolutionrR2 oligemiaisinaccordancewiththeunderl