BMP9-Induced Osteogenetic Differentiation and Bone Formation of Muscle-Derived Stem Cells英文文献资料.docVIP

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BMP9-Induced Osteogenetic Differentiation and Bone Formation of Muscle-Derived Stem Cells英文文献资料.doc

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BMP9-Induced Osteogenetic Differentiation and Bone Formation of Muscle-Derived Stem Cells英文文献资料

HindawiPublishingCorporation JournalofBiomedicineandBiotechnology Volume2012,ArticleID610952,7pages doi:10.1155/2012/610952 ResearchArticle BMP9-InducedOsteogeneticDifferentiationandBoneFormation ofMuscle-DerivedStemCells LiXiang,ChenLiang,KeZhen-Yong,YinLiang-Jun,andDengZhong-Liang DepartmentofOrthopaedicSurgery,TheSecondA?liatedHospital,ChongqingMedicalUniversity,No.76LinjiangRoad,Yuzhong District,Chongqing400010,China CorrespondenceshouldbeaddressedtoDengZhong-Liang,deng7586@ Received15July2011;Accepted26October2011 AcademicEditor:Ken-ichiIsobe Copyright?2012LiXiangetal.ThisisanopenaccessarticledistributedundertheCreativeCommonsAttributionLicense,which permitsunrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited. E?cientosteogeneticdi?erentiationandboneformationfrommuscle-derivedstemcells(MDSCs)shouldhavepotentialclinical applicationsintreatingnonunionfracturehealingorbonedefects.Here,weinvestigateosteogeneticdi?erentiationabilityof MDSCsinducedbybonemorphogeneticprotein9(BMP9)invitroandboneformationabilityinrabbitradiusdefectsrepairing model.Rabbit’sMDSCswereextractedbytypeIcollagenaseandtrypsinmethods,andBMP9wasintroducedintoMDSCsby infection with recombinant adenovirus. E?ects of BMP9-induced osteogenetic di?erentiation ofMDSCs were identi?ed with alkalinephosphatase(ALP)activity andexpressionoflatermarker.Instem-cellimplantationassay,MDSCshavealsoshown valuablepotentialboneformationabilityinducedbyBMP9inrabbitradiusdefectsrepairingtest.Takentogether,our?ndings suggestthatMDSCsarepotentiatedosteogeneticstemcellswhichcanbeinducedbyBMP9totreatlargesegmentalbonedefects, nonunionfracture,and/orosteoporoticfracture. 1.Introduction (TGFs);BMPsareakindofmultifunctionalgrowthfactors andareoneofthemostpotentosteogeneticgrowthfactors [6–8]. BMP9 belongs to BMPs family and is expressed in liver [9]. BMP9 possible roles include inducing and maintainingthecholinergicphenotype ofembryonicbasal forebrain cholinergic neurons, inhibit